GUF1/YLR289W Protein Information Help

Standard Name Guf1p 1
Systematic Name Ylr289wp
ORF Classification Verified
Description Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor (1, 2)
Name Description Gtpase of Unknown Function 1
Experimental Data
Molecules/cell 1890 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 645
Molecular Weight (Da) 73,188
Isoelectric Point (pI) 9.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Guf1p (InterPro)
Physical Interactions There are 5 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012BD9E | P46943
MIPS: YLR289W
NCBI: 2506379 | 596037 | 6323320 | 722349 | NP_013392.1 | NM_001182177.1
GenBank/EMBL/DDBJ: AAA96351.1 | AAB67335.1 | DAA09601.1 | U17243 | U22360
External Classifications EC: 3.6.5.- [Hydrolases, Acting on GTP; involved in cellular and subcellular movement]
Amino Acid Sequence (or in FASTA format)
       1  MLKFRIRPVR HIRCYKRHAY FLRYNHTTTP AQKLQAQIEQ IPLENYRNFS
      51  IVAHVDHGKS TLSDRLLEIT HVIDPNARNK QVLDKLEVER ERGITIKAQT
     101  CSMFYKDKRT GKNYLLHLID TPGHVDFRGE VSRSYASCGG AILLVDASQG
     151  IQAQTVANFY LAFSLGLKLI PVINKIDLNF TDVKQVKDQI VNNFELPEED
     201  IIGVSAKTGL NVEELLLPAI IDRIPPPTGR PDKPFRALLV DSWYDAYLGA
     251  VLLVNIVDGS VRKNDKVICA QTKEKYEVKD IGIMYPDRTS TGTLKTGQVG
     301  YLVLGMKDSK EAKIGDTIMH LSKVNETEVL PGFEEQKPMV FVGAFPADGI
     351  EFKAMDDDMS RLVLNDRSVT LERETSNALG QGWRLGFLGS LHASVFRERL
     401  EKEYGSKLII TQPTVPYLVE FTDGKKKLIT NPDEFPDGAT KRVNVAAFHE
     451  PFIEAVMTLP QEYLGSVIRL CDSNRGEQID ITYLNTNGQV MLKYYLPLSH
     501  LVDDFFGKLK SVSRGFASLD YEDAGYRISD VVKLQLLVNG NAIDALSRVL
     551  HKSEVERVGR EWVKKFKEYV KSQLYEVVIQ ARANNKIIAR ETIKARRKDV
     601  LQKLHASDVS RRKKLLAKQK EGKKHMKTVG NIQINQEAYQ AFLRR*    

external links for Guf1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Guf1p
1) Kiser GL and Weinert TA  (1995) GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Yeast 11(13):1311-6
2) Bauerschmitt H, et al.  (2008) The Membrane-bound GTPase Guf1 Promotes Mitochondrial Protein Synthesis under Suboptimal Conditions. J Biol Chem 283(25):17139-46
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41