YLR278C Protein Information

Systematic Name	Ylr278cp
ORF Classification	Uncharacterized
Description	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene (1, 2, 3, 4)

Experimental Data
Molecules/cell	1080 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,341
Molecular Weight (Da)	151,277
Isoelectric Point (pI)	8.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ylr278cp (InterPro)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B7E0 \| Q05854 MIPS: YLR278C NCBI: 2340973 \| 2501739 \| 596040 \| 6323308 \| NP_013380.1 GenBank/EMBL/DDBJ: DAA09591.1 \| U17243 \| U17245

Amino Acid Sequence (or in FASTA format)
1 MGRPRKNVSQ EKIQQLKREL ELAGNRTDVL LQDKKGRSRS CLLCRRRKQR 51 CDHKLPSCTA CLKAGIKCVQ PSKYSSSTSN SNTNNNTPTA GTVPPTPHPV 101 IKRELQDSSI GAGAGAATSL NDMTIIKPIS TSNSNVDAGD ANEFRKTIKS 151 VTTNSNPNLM RQDKDQYTIF LEKKLKSLET LLDLSPGCNQ YNYELSQYKK 201 VSHLFSNNTS DYSRPNSSNM VILPLPSPSN KPLENTNNNG SNVNAATNDT 251 SASTNNINNN NAICQSASLL NDPLETLDFT KCIFAKYNLK KEFLMYDPIF 301 ELNEKLSRSF LDTFFTRLQF KYPILDEQEI YTFYDHYLHN KILIPPSSPA 351 TSSAAPPSNS HSYSEIEFHF LSGRMWLVFS ISAYLLMTTG KYKGFPPHRY 401 FSTAIRHITK CGLHLNYVQQ IELLTLLVLY IIRTDRDSLI LYDIIKDVMG 451 ISKKKLHLNQ WYPNDPFANK KLRLFWCVYL LERMICVAVG KPYTIKESEI 501 NLPLFNNDSF YTKGVHAAAP STNDHGVQFI NQSLKLRRIE SQFVETLQLL 551 KNDSRSVKQS IDQLPLVRKF FEDLEVWRKS YSTLDVKNFE NETLKLYYYR 601 SVRLLIQPYL EFFAPEDRLF RECQAAAGQI CQLYKIFHQK TLNGHSTPAV 651 HTVFVAGVTL IYCMWLARNF DDQRRKKLGD ASKHTRPLIS ASLFSTMDDL 701 RACSVCLYVM TERSNFARTF RDTFDQLMNA TVGNLIERCG PDSSELIFMA 751 SSVAKRTEPK NINDEANKAI SSGDTLHDSN SANAANLSNS NDKNISHNGG 801 MPPAVARIFG KGQAEEHAGF VENSQVDLAE QEKFKKKQGV LEKTSVPKSL 851 AHLLTKMDDR SRISNSSMSY TTSSSSSSSS SSSSSTLSFP SSQEKNLKIN 901 VNNDNNGMTI SSVNREHNNN HNNNNDNNNN NNNNNNNSNN NNNVNNNDNE 951 SNSRSTTNNS CNNGNNSQYV RNNNVTMEND VERPIQDQYI VKKPTNQTEF 1001 DWQVFQQQAF LQQQLAQHNL QAYLSSLNTD TMTNRSPSKS SSISTASSHS 1051 DPIPIAMTQS PTPYPQTSNM LPQQHVSRPL PQQQREQPQQ HITSPQRFSE 1101 SNFTNQLNNG MINSNPLQSA IFSNHTSENK QLRDVEESNF STSPLRADYG 1151 NNIISSIPAS FTSNSIPVSV KQARNGSSSG DILFSNGAHD MINNISTWTN 1201 NSVLDALNSK SILQTIFPQS QEPSSLSMDK QQQQHQQQNM CSENNVTANN 1251 FQQTQNDPSY NRNLFMMSNQ EGVQYNLDET EKNGPKTQVE ANTSANLHFD 1301 NVIPTVTNAD IRKKRSNWDN MMTSGPVEDF WTINDDYGFL T*

Amino Acid Sequence (or in FASTA format)

       1  MGRPRKNVSQ EKIQQLKREL ELAGNRTDVL LQDKKGRSRS CLLCRRRKQR
      51  CDHKLPSCTA CLKAGIKCVQ PSKYSSSTSN SNTNNNTPTA GTVPPTPHPV
     101  IKRELQDSSI GAGAGAATSL NDMTIIKPIS TSNSNVDAGD ANEFRKTIKS
     151  VTTNSNPNLM RQDKDQYTIF LEKKLKSLET LLDLSPGCNQ YNYELSQYKK
     201  VSHLFSNNTS DYSRPNSSNM VILPLPSPSN KPLENTNNNG SNVNAATNDT
     251  SASTNNINNN NAICQSASLL NDPLETLDFT KCIFAKYNLK KEFLMYDPIF
     301  ELNEKLSRSF LDTFFTRLQF KYPILDEQEI YTFYDHYLHN KILIPPSSPA
     351  TSSAAPPSNS HSYSEIEFHF LSGRMWLVFS ISAYLLMTTG KYKGFPPHRY
     401  FSTAIRHITK CGLHLNYVQQ IELLTLLVLY IIRTDRDSLI LYDIIKDVMG
     451  ISKKKLHLNQ WYPNDPFANK KLRLFWCVYL LERMICVAVG KPYTIKESEI
     501  NLPLFNNDSF YTKGVHAAAP STNDHGVQFI NQSLKLRRIE SQFVETLQLL
     551  KNDSRSVKQS IDQLPLVRKF FEDLEVWRKS YSTLDVKNFE NETLKLYYYR
     601  SVRLLIQPYL EFFAPEDRLF RECQAAAGQI CQLYKIFHQK TLNGHSTPAV
     651  HTVFVAGVTL IYCMWLARNF DDQRRKKLGD ASKHTRPLIS ASLFSTMDDL
     701  RACSVCLYVM TERSNFARTF RDTFDQLMNA TVGNLIERCG PDSSELIFMA
     751  SSVAKRTEPK NINDEANKAI SSGDTLHDSN SANAANLSNS NDKNISHNGG
     801  MPPAVARIFG KGQAEEHAGF VENSQVDLAE QEKFKKKQGV LEKTSVPKSL
     851  AHLLTKMDDR SRISNSSMSY TTSSSSSSSS SSSSSTLSFP SSQEKNLKIN
     901  VNNDNNGMTI SSVNREHNNN HNNNNDNNNN NNNNNNNSNN NNNVNNNDNE
     951  SNSRSTTNNS CNNGNNSQYV RNNNVTMEND VERPIQDQYI VKKPTNQTEF
    1001  DWQVFQQQAF LQQQLAQHNL QAYLSSLNTD TMTNRSPSKS SSISTASSHS
    1051  DPIPIAMTQS PTPYPQTSNM LPQQHVSRPL PQQQREQPQQ HITSPQRFSE
    1101  SNFTNQLNNG MINSNPLQSA IFSNHTSENK QLRDVEESNF STSPLRADYG
    1151  NNIISSIPAS FTSNSIPVSV KQARNGSSSG DILFSNGAHD MINNISTWTN
    1201  NSVLDALNSK SILQTIFPQS QEPSSLSMDK QQQQHQQQNM CSENNVTANN
    1251  FQQTQNDPSY NRNLFMMSNQ EGVQYNLDET EKNGPKTQVE ANTSANLHFD
    1301  NVIPTVTNAD IRKKRSNWDN MMTSGPVEDF WTINDDYGFL T*

external links for Ylr278cp

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ylr278cp

1)	Akache B, et al. (2001) Phenotypic analysis of genes encoding yeast zinc cluster proteins. Nucleic Acids Res 29(10):2181-90
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4)	Ross CD, et al. (2009) A Promiscuous Prion: Efficient Induction of [URE3] Prion Formation by Heterologous Prion Domains. Genetics 183(3):929-40
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41