DBP9/YLR276C Protein Information

Standard Name	Dbp9p 1
Systematic Name	Ylr276cp
ORF Classification	Verified
Description	DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain (1, 2)
Name Description	Dead Box Protein 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	594
Molecular Weight (Da)	68,059
Isoelectric Point (pI)	9.97

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dbp9p (InterPro)
Physical Interactions	There are 71 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FE4 \| Q06218 MIPS: YLR276C NCBI: 2500536 \| 51830470 \| 577189 \| 6323306 \| NP_013378.1 GenBank/EMBL/DDBJ: DAA09589.1 \| AY723847 \| U17245
External Classifications	EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]

Amino Acid Sequence (or in FASTA format)
1 MSYEKKSVEG AYIDDSTTFE AFHLDSRLLQ AIKNIGFQYP TLIQSHAIPL 51 ALQQKRDIIA KAATGSGKTL AYLIPVIETI LEYKKTIDNG EENGTLGIIL 101 VPTRELAQQV YNVLEKLVLY CSKDIRTLNI SSDMSDSVLS TLLMDQPEII 151 VGTPGKLLDL LQTKINSISL NELKFLVVDE VDLVLTFGYQ DDLNKIGEYL 201 PLKKNLQTFL MSATLNDDIQ ALKQKFCRSP AILKFNDEEI NKNQNKLLQY 251 YVKVSEFDKF LLCYVIFKLN LIKGKTLIFV NNIDRGYRLK LVMEQFGIKS 301 CILNSELPVN SRQHIVDQFN KNVYQLLIAT DDTEYIKEED DEIEEGHNTE 351 NQEEKSLEGE PENDKKPSKK KKVQVKKDKE YGVSRGVDFK NVACVLNFDL 401 PTTAKSYVHR VGRTARGGKT GTAISFVVPL KEFGKHKPSM LQTAKKDERI 451 LSRIIKQQSK LGLELQPYKF DQKQVEAFRY RMEDGFRAVT QVAIREARVK 501 ELKQELLASE KLKRHFEENP KELQSLRHDK ELHPARVQQH LKRVPDYLLP 551 ESARGNGTKV KFVPFHNAKK RHSHKKGRVS KPKNGKVDPL KNFK*

Amino Acid Sequence (or in FASTA format)

       1  MSYEKKSVEG AYIDDSTTFE AFHLDSRLLQ AIKNIGFQYP TLIQSHAIPL
      51  ALQQKRDIIA KAATGSGKTL AYLIPVIETI LEYKKTIDNG EENGTLGIIL
     101  VPTRELAQQV YNVLEKLVLY CSKDIRTLNI SSDMSDSVLS TLLMDQPEII
     151  VGTPGKLLDL LQTKINSISL NELKFLVVDE VDLVLTFGYQ DDLNKIGEYL
     201  PLKKNLQTFL MSATLNDDIQ ALKQKFCRSP AILKFNDEEI NKNQNKLLQY
     251  YVKVSEFDKF LLCYVIFKLN LIKGKTLIFV NNIDRGYRLK LVMEQFGIKS
     301  CILNSELPVN SRQHIVDQFN KNVYQLLIAT DDTEYIKEED DEIEEGHNTE
     351  NQEEKSLEGE PENDKKPSKK KKVQVKKDKE YGVSRGVDFK NVACVLNFDL
     401  PTTAKSYVHR VGRTARGGKT GTAISFVVPL KEFGKHKPSM LQTAKKDERI
     451  LSRIIKQQSK LGLELQPYKF DQKQVEAFRY RMEDGFRAVT QVAIREARVK
     501  ELKQELLASE KLKRHFEENP KELQSLRHDK ELHPARVQQH LKRVPDYLLP
     551  ESARGNGTKV KFVPFHNAKK RHSHKKGRVS KPKNGKVDPL KNFK*

external links for Dbp9p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Dbp9p

1)	Daugeron MC, et al. (2001) Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6p. RNA 7(9):1317-34
2)	Kikuma T, et al. (2004) Dbp9p, a member of the DEAD box protein family, exhibits DNA helicase activity. J Biol Chem 279(20):20692-8