YCS4/YLR272C Protein Information

Standard Name	Ycs4p
Systematic Name	Ylr272cp
Alias	Loc7p 1
ORF Classification	Verified
Description	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation (1, 2, 3, 4, 5, 6)
Name Description	Yeast Condensin Subunit 2

Experimental Data
Molecules/cell	2540 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,176
Molecular Weight (Da)	132,966
Isoelectric Point (pI)	5.36

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ycs4p (InterPro)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C1CC \| Q06156 MIPS: YLR272C NCBI: 2340972 \| 31076624 \| 577185 \| 6323302 \| NP_013374.1 GenBank/EMBL/DDBJ: DAA09585.1 \| U17244 \| U17245

Amino Acid Sequence (or in FASTA format)
1 MSGFSLSEYL TKFQTTDRES YPRLQDPSRE LNVIIDQLAV SPEQIDASPD 51 SLEALIDLCH DFPHLTPKLQ TQLSYLISSS LSNLSKDIKA NLSSNVNFTE 101 IGGLIPQWKR HLEEYGYLIQ VLLTFLQDEL HKVSSQSTNL NRSAKNSKND 151 SANVELFKRD CNQMENLLES ITKLLEINLS KIFQTTPEKD LFIGLFTRPL 201 FVLLEIEPVT KVSSLKMFIQ RILAMCVKNH GQSSSIQSSL MTNLTYFLHL 251 SVFNAELLKL LNDEYNYPQL TEDILKEIST RVFNAKDTTG PKAISNFLIK 301 LSELSPGIML RQMNLVITLL NNSSITLRCS VVEACGNIVA ELAQDPQTME 351 HYKQQIAVLI ELLEERFQDS NPYVRTKAIQ GCSKICDLSS KFNKSKAKFT 401 SLAVRSLQDR SSLVRRNSVK LLSKLLLKHP FKAIHGSQLR LSEWEEYLKG 451 SESQLNSTLK KVESQETLND TIERSLIEEE VEQDEGQCRT ELEGSFNKSA 501 ELSRIENEVE NINATNTSVL MKLKLMIVYY KDAISFIKEI HKSIELISNL 551 LFSKNRNEVL ESMDFLVLAD AFDIELSEFG IKKMLHLVWM KGTNDEGTSI 601 SVHLIECYKQ LFLTAPDSCN MQEKAAHIAK NLINLSIGAS IADLASLEQL 651 LGMMYEQKLI DQHVINILWA IYNSASKASM QKEQNVNNRD SEKGFSKEQI 701 HGSIIILGML SLADNEIALK GLESLLNIGL GAVGLKDLTL CRYSCLALER 751 MVPKRSTIIT KAINQELEDV AVKKLYAIII NYTKDNEYYP MCEQALSALF 801 TISSKPDILA TDLIREKTMM TFGKPEEEDS ILSLEQSSRV VSLSQLLFIV 851 GQVAIKTLVY LEKCEAEFKK RKIEAETRNG KVKNQGADVT NTTQDNGGDK 901 ELEMIGGTNE DDFTDAIQFV KENELLFGEK SILGKFCPIV EEIVSNSSRF 951 SDPMLQRTAT LCLEKLMCLS SKYCEKSLPL LITVMEKSPD PTIRSNAVLG 1001 LGDMAVCFNN LVDENTDYLY RRLHDENLMV QRTCLMTVTF LILAGQVKVK 1051 GQLGEMAKCL DNPDQGISDM CRLFFTELAS KDNAIYNGFI DIFSNLSSDD 1101 LLGKESFKKI IKFLLTFIDK ERHQKQLNEK LVGRLRKCET QKQWDDIAFV 1151 LNNLPYKNED VTALLEQGFK VVSAKE*

Amino Acid Sequence (or in FASTA format)

       1  MSGFSLSEYL TKFQTTDRES YPRLQDPSRE LNVIIDQLAV SPEQIDASPD
      51  SLEALIDLCH DFPHLTPKLQ TQLSYLISSS LSNLSKDIKA NLSSNVNFTE
     101  IGGLIPQWKR HLEEYGYLIQ VLLTFLQDEL HKVSSQSTNL NRSAKNSKND
     151  SANVELFKRD CNQMENLLES ITKLLEINLS KIFQTTPEKD LFIGLFTRPL
     201  FVLLEIEPVT KVSSLKMFIQ RILAMCVKNH GQSSSIQSSL MTNLTYFLHL
     251  SVFNAELLKL LNDEYNYPQL TEDILKEIST RVFNAKDTTG PKAISNFLIK
     301  LSELSPGIML RQMNLVITLL NNSSITLRCS VVEACGNIVA ELAQDPQTME
     351  HYKQQIAVLI ELLEERFQDS NPYVRTKAIQ GCSKICDLSS KFNKSKAKFT
     401  SLAVRSLQDR SSLVRRNSVK LLSKLLLKHP FKAIHGSQLR LSEWEEYLKG
     451  SESQLNSTLK KVESQETLND TIERSLIEEE VEQDEGQCRT ELEGSFNKSA
     501  ELSRIENEVE NINATNTSVL MKLKLMIVYY KDAISFIKEI HKSIELISNL
     551  LFSKNRNEVL ESMDFLVLAD AFDIELSEFG IKKMLHLVWM KGTNDEGTSI
     601  SVHLIECYKQ LFLTAPDSCN MQEKAAHIAK NLINLSIGAS IADLASLEQL
     651  LGMMYEQKLI DQHVINILWA IYNSASKASM QKEQNVNNRD SEKGFSKEQI
     701  HGSIIILGML SLADNEIALK GLESLLNIGL GAVGLKDLTL CRYSCLALER
     751  MVPKRSTIIT KAINQELEDV AVKKLYAIII NYTKDNEYYP MCEQALSALF
     801  TISSKPDILA TDLIREKTMM TFGKPEEEDS ILSLEQSSRV VSLSQLLFIV
     851  GQVAIKTLVY LEKCEAEFKK RKIEAETRNG KVKNQGADVT NTTQDNGGDK
     901  ELEMIGGTNE DDFTDAIQFV KENELLFGEK SILGKFCPIV EEIVSNSSRF
     951  SDPMLQRTAT LCLEKLMCLS SKYCEKSLPL LITVMEKSPD PTIRSNAVLG
    1001  LGDMAVCFNN LVDENTDYLY RRLHDENLMV QRTCLMTVTF LILAGQVKVK
    1051  GQLGEMAKCL DNPDQGISDM CRLFFTELAS KDNAIYNGFI DIFSNLSSDD
    1101  LLGKESFKKI IKFLLTFIDK ERHQKQLNEK LVGRLRKCET QKQWDDIAFV
    1151  LNNLPYKNED VTALLEQGFK VVSAKE*

external links for Ycs4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ycs4p

1)	Biggins S, et al. (2001) Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics 159(2):453-70
2)	Freeman L, et al. (2000) The condensin complex governs chromosome condensation and mitotic transmission of rDNA. J Cell Biol 149(4):811-24
3)	Lavoie BD, et al. (2002) In vivo dissection of the chromosome condensation machinery: reversibility of condensation distinguishes contributions of condensin and cohesin. J Cell Biol 156(5):805-15
4)	Bhalla N, et al. (2002) Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Mol Biol Cell 13(2):632-45
5)	Haeusler RA, et al. (2008) Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev 22(16):2204-14
6)	Hashash N, et al. (2012) Topoisomerase II- and Condensin-Dependent Breakage of MEC1(ATR)-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis. PLoS Genet 8(10):e1002978
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41