PDR8/YLR266C Protein Information Help

Standard Name Pdr8p 1
Systematic Name Ylr266cp
ORF Classification Verified
Description Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication (1, 2)
Name Description Pleiotropic Drug Resistance 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 701
Molecular Weight (Da) 81,273
Isoelectric Point (pI) 6.8

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pdr8p (InterPro)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B7DB | Q06149
MIPS: YLR266C
NCBI: 20978807 | 577184 | 6323296 | NP_013368.1 | NM_001182153.1
GenBank/EMBL/DDBJ: AAB67383.1 | DAA09580.1 | U17244
Amino Acid Sequence (or in FASTA format)
       1  MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ
      51  CVIRKLPQCV YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN
     101  NAKPVYCRSS ENPLRSLRTS VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE
     151  FQNLWKVLKP LPECTKSQLN ENDVVADLPS FPQMESCIKS FFAGPLFGIL
     201  HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN LGIVLQILCL
     251  GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD
     301  GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL
     351  FLDVSTSYDI GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV
     401  SRFTTREIHK REMNEKLTTF SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF
     451  DILILSRSLS IVASIYNIEM IIAQQSRIID KNRMVQFLLI SISVCVNTMV
     501  FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA FNRLIFREKA
     551  FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI
     601  IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK
     651  IWLKKGINME HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD
     701  L*                                                    

external links for Pdr8p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains YeastRC Public Image Repository

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Pdr8p
1) Hikkel I, et al.  (2003) A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J Biol Chem 278(13):11427-32
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61