PDR8/YLR266C Protein Information

Standard Name	Pdr8p 1
Systematic Name	Ylr266cp
ORF Classification	Verified
Description	Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication (1, 2)
Name Description	Pleiotropic Drug Resistance 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	701
Molecular Weight (Da)	81,273
Isoelectric Point (pI)	6.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pdr8p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B7DB \| Q06149 MIPS: YLR266C NCBI: 20978807 \| 577184 \| 6323296 \| NP_013368.1 GenBank/EMBL/DDBJ: DAA09580.1 \| U17244

Amino Acid Sequence (or in FASTA format)
1 MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ 51 CVIRKLPQCV YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN 101 NAKPVYCRSS ENPLRSLRTS VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE 151 FQNLWKVLKP LPECTKSQLN ENDVVADLPS FPQMESCIKS FFAGPLFGIL 201 HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN LGIVLQILCL 251 GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD 301 GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL 351 FLDVSTSYDI GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV 401 SRFTTREIHK REMNEKLTTF SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF 451 DILILSRSLS IVASIYNIEM IIAQQSRIID KNRMVQFLLI SISVCVNTMV 501 FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA FNRLIFREKA 551 FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI 601 IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK 651 IWLKKGINME HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD 701 L*

Amino Acid Sequence (or in FASTA format)

       1  MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ
      51  CVIRKLPQCV YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN
     101  NAKPVYCRSS ENPLRSLRTS VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE
     151  FQNLWKVLKP LPECTKSQLN ENDVVADLPS FPQMESCIKS FFAGPLFGIL
     201  HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN LGIVLQILCL
     251  GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD
     301  GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL
     351  FLDVSTSYDI GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV
     401  SRFTTREIHK REMNEKLTTF SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF
     451  DILILSRSLS IVASIYNIEM IIAQQSRIID KNRMVQFLLI SISVCVNTMV
     501  FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA FNRLIFREKA
     551  FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI
     601  IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK
     651  IWLKKGINME HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD
     701  L*

external links for Pdr8p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pdr8p

1)	Hikkel I, et al. (2003) A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J Biol Chem 278(13):11427-32
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61