YPT6/YLR262C Protein Information

Standard Name	Ypt6p 1
Systematic Name	Ylr262cp
ORF Classification	Verified
Description	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 (1, 2, 3)
Name Description	Yeast Protein Two 1

Experimental Data
Molecules/cell	7720 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	215
Molecular Weight (Da)	24,412
Isoelectric Point (pI)	5.58

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ypt6p (InterPro)
Physical Interactions	There are 63 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BE46 \| Q99260 MIPS: YLR262C NCBI: 2500077 \| 45269764 \| 577182 \| 6323291 \| 927545 \| NP_013363.1 GenBank/EMBL/DDBJ: DAA09574.1 \| AY557936 \| U17244 \| X59598

Amino Acid Sequence (or in FASTA format)
1 MSRSGKSLTK YKIVFLGEQG VGKTSLITRF MYDTFDDHYQ ATIGIDFLSK 51 TMYLDDKTIR LQLWDTAGQE RFRSLIPSYI RDSRVAIIVY DITKRKSFEY 101 IDKWIEDVKN ERGDENVILC IVGNKSDLSD ERQISTEEGE KKAKLLGAKI 151 FMETSTKAGY NVKALFKKIA KSLPEFQNSE STPLDSENAN SANQNKPGVI 201 DISTAEEQEQ SACQC*

Amino Acid Sequence (or in FASTA format)

       1  MSRSGKSLTK YKIVFLGEQG VGKTSLITRF MYDTFDDHYQ ATIGIDFLSK
      51  TMYLDDKTIR LQLWDTAGQE RFRSLIPSYI RDSRVAIIVY DITKRKSFEY
     101  IDKWIEDVKN ERGDENVILC IVGNKSDLSD ERQISTEEGE KKAKLLGAKI
     151  FMETSTKAGY NVKALFKKIA KSLPEFQNSE STPLDSENAN SANQNKPGVI
     201  DISTAEEQEQ SACQC*

external links for Ypt6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ypt6p

1)	Li B and Warner JR (1996) Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J Biol Chem 271(28):16813-9
2)	Lazar T, et al. (1997) Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? Trends Biochem Sci 22(12):468-72
3)	Luo Z and Gallwitz D (2003) Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments. J Biol Chem 278(2):791-9
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41