IRC20/YLR247C Protein Information Help

Standard Name Irc20p 1
Systematic Name Ylr247cp
ORF Classification Verified
Description Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci (1, 2, 3, 4, 5)
Name Description Increased Recombination Centers 1
Experimental Data
Molecules/cell 143 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,556
Molecular Weight (Da) 180,342
Isoelectric Point (pI) 6.5

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Irc20p (InterPro)
Physical Interactions There are 8 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000069EBE | Q06554
MIPS: YLR247C
NCBI: 6323276 | 662344 | 74676414 | NP_013348.1
GenBank/EMBL/DDBJ: DAA09561.1 | U20865
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
Amino Acid Sequence (or in FASTA format)
 
       1  MSAVGALLAR EYNVTAEKCD FFLENGSFDS VIAALPALNQ EQETVTQKVS
      51  KNGKELINVA SVNIEIPERI SLSNNGRQLF KFIVDIEILP CENDNEATLV
     101  VSSDSVSLFQ IGFKMENNSK IAVDKQLPLI LDICAHKNQE RALRNQLENR
     151  KSLERKPSRK RRKKNSNVND PEKLLKSRIH ELSLSYKDFE CSPVVFRYND
     201  SSLTWVLSFN LKLKFLNNKF NRFSVEANQI LDLTFSNRDE NEFERYHKHS
     251  HIHSNFIQKQ FISQILEYSK DRLSKIKPFL PQSIPDLKVN LLPFQRESVE
     301  WMLIKEGHGN SLSDTPTVID EVGLIDFMNE YYAYGYELIA RSPDEVGPSL
     351  LWNKLTGYIL TTEDAAHLYN QYRKERLSGD YPVCAKGVLA EEMGLGKTIE
     401  ILSLILLNRR KLKDSEATFI DDENRTITKT KTTLIICPNA ILKQWLEEIE
     451  LHANSLKWYT YRGYNEIMKD CKTVDEAVQQ LCQYDIIVTS YNIIATEVHH
     501  AEFNRSIRSR RLKSPKYDYS SPLALMQFYR IILDEVQMLR SSSTYSAKCT
     551  SLLHRIHTWG VSGTPIQNIY NFRMIMSYLK LHPFCDEVDF IRTLQEEIKL
     601  RNEAKDYTSN DFVCQLKGVR FSIKDCMNIF YRYDLCIRHS KANVASQIHI
     651  PRQHNFIIPL EFAPIEWDNY LNLWNNFLEL SGYNSDGSGS PRVSNAFLNE
     701  WLSRLRYICC HALFPEILST RQKRLHGHLS RISNIDDILI SMRMDAFDSL
     751  IGYYRERFHL SIKQAQYELE ISNTPAKALE SFIKIRDDLM IHIRQKFNVE
     801  DPFDKSLNLS EDEDEHMDER FGEKETSSGD ESDREINGAK NHDNHNNDGM
     851  LSNHLKKKGL RAMMNLLHDC YFFLGSVYYN LGTRKLEEAD DKHRKEKTEE
     901  VVYSDVFPKN ELEEIEENRL LEQENYANAE ILRKSILSSE ARKVDMTIKM
     951  ARTKFAPMTS NIPLRLINIE FDHKNDYSSN LAVSRCFKSL SKLIEGLNEQ
    1001  TKNFNELLDE LLIIIYEPVH RTEDDDSTNK IIGNEEYSTS IDSQDKIFSL
    1051  LGCLEIILQN RDNILTSESE VKIPKHLVPE GSIISKYQKQ LLNSLRLISG
    1101  TPLRTVFDEL KNSRIVRRIS SSNESESTIQ NFEDYLLQYE VESKSLFKYN
    1151  KQVRESLKIL GSIYNAKTEY YSQLQRISDS LVSLHSLSAP QLSHLIRTIN
    1201  KSLGGTLDAK INNIESRLIY LKNLSRLKDT LNDNQILSCS ICLGEVEIGA
    1251  IIKCGHYFCK SCILTWLRAH SKCPICKGFC SISEVYNFKF KNSTEKREKE
    1301  IQEPRREGAD SSQDNSNENS IISNMSEVEK LFGNKYEQFH QINEVHQIHI
    1351  KESFGAKIDF VIKLISYLRL KSEQENADPP QVILYSQKTE YLKVIGKVLK
    1401  LYHIEHLACL SNTANVGETI NNFKRQPSVT CLLLNVKTLG AGLNLINAKH
    1451  IFLLDPILNN SDELQAMGRN NRIGQDEETF VWNFMIRNTV EENILRYKCI
    1501  LEERKRKEKS KKGDKYDEAQ DETDNEESDD AKFEISVVDQ EVSNEHLWNC
    1551  FFHGSD*

external links for Irc20p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Irc20p
1) Alvaro D, et al.  (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2) Shiratori A, et al.  (1999) Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis. Yeast 15(3):219-53
3) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41