GPN3/YLR243W Protein Information

Standard Name	Gpn3p 1
Systematic Name	Ylr243wp
ORF Classification	Verified
Description	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p (2, 3, 4)
Name Description	Gly-Pro-Asn (N) motif 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	272
Molecular Weight (Da)	30,653
Isoelectric Point (pI)	4.21

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gpn3p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A6CF \| Q06543 MIPS: YLR243W NCBI: 6323272 \| 662338 \| 74644965 \| NP_013344.1 GenBank/EMBL/DDBJ: DAA09557.1 \| U20865

Amino Acid Sequence (or in FASTA format)
1 MSRVGVMVLG PAGAGKSTFC NSIISHMQTV GRRAHIVNLD PAAEATKYEF 51 TIDIRDLISL DDVMEEMDLG PNGALIYCFE YLLKNLDWLD EEIGDFNDEY 101 LIFDCPGQIE LYTHIPVLPN IVRHLTQQLN FNLCATYLLE APFVIDSSKF 151 FSGALSAMSA MILLELPHIN VLSKLDLIKG DINKKKLKRF LNPDAMLLME 201 TEGMNQASNP KFLRLNQCIA NLVDDFGMVQ FLPLESNNPD SIETILSYVD 251 DITQWAEGQE QKEPNDQIDV EE*

Amino Acid Sequence (or in FASTA format)

       1  MSRVGVMVLG PAGAGKSTFC NSIISHMQTV GRRAHIVNLD PAAEATKYEF
      51  TIDIRDLISL DDVMEEMDLG PNGALIYCFE YLLKNLDWLD EEIGDFNDEY
     101  LIFDCPGQIE LYTHIPVLPN IVRHLTQQLN FNLCATYLLE APFVIDSSKF
     151  FSGALSAMSA MILLELPHIN VLSKLDLIKG DINKKKLKRF LNPDAMLLME
     201  TEGMNQASNP KFLRLNQCIA NLVDDFGMVQ FLPLESNNPD SIETILSYVD
     251  DITQWAEGQE QKEPNDQIDV EE*

external links for Gpn3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Gpn3p

1)	Alonso B, et al. (2011) A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion. Cell Cycle 10(11):1828-37
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Minaker SW, et al. (2013) Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae. Genetics 193(3):853-64
4)	Alonso B, et al. (2013) Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Cell Cycle 12(3):463-72