HMX1/YLR205C Protein Information

Standard Name	Hmx1p
Systematic Name	Ylr205cp
ORF Classification	Verified
Description	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants (1, 2, 3, 4, 5)
Name Description	HeMe oXygenase 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	317
Molecular Weight (Da)	37,179
Isoelectric Point (pI)	7.97

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hmx1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000023C991 \| P32339 MIPS: YLR205C NCBI: 255247 \| 30267758 \| 42544111 \| 42742287 \| 50897842 \| NP_013306.2 GenBank/EMBL/DDBJ: DAA09522.1 \| AY260884 \| S43721 \| U14913

Amino Acid Sequence (or in FASTA format)
1 MEDSSNTIIP SPTDVGALAN RINFQTRDAH NKINTFMGIK MAIAMRHGFI 51 YRQGILAYYY VFDAIEQEID RLLNDPVTEE ELQTSTILKQ FWLEDFRRST 101 QIYKDLKLLY SNTFKSTESL NEFLATFQKP PLLQQFINNI HENIHKEPCT 151 ILSYCHVLYL ALFAGGKLIR SNLYRRLGLF PNFEKLSQKE LVKKGTNFFT 201 FSDLGPTEET RLKWEYKKNY ELATRTELTE AQKLQIISVA EGIFDWNFNI 251 VAEIGELNRR ELMGKFSFKC ITYLYEEWMF NKDSATRRAL HTVMLLVLSI 301 IAIWVLYFLV KSFLSIV*

Amino Acid Sequence (or in FASTA format)

       1  MEDSSNTIIP SPTDVGALAN RINFQTRDAH NKINTFMGIK MAIAMRHGFI
      51  YRQGILAYYY VFDAIEQEID RLLNDPVTEE ELQTSTILKQ FWLEDFRRST
     101  QIYKDLKLLY SNTFKSTESL NEFLATFQKP PLLQQFINNI HENIHKEPCT
     151  ILSYCHVLYL ALFAGGKLIR SNLYRRLGLF PNFEKLSQKE LVKKGTNFFT
     201  FSDLGPTEET RLKWEYKKNY ELATRTELTE AQKLQIISVA EGIFDWNFNI
     251  VAEIGELNRR ELMGKFSFKC ITYLYEEWMF NKDSATRRAL HTVMLLVLSI
     301  IAIWVLYFLV KSFLSIV*

external links for Hmx1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hmx1p

1)	Foury F and Talibi D (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J Biol Chem 276(11):7762-8
2)	Auclair K, et al. (2003) Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 28(2):340-9
3)	Protchenko O and Philpott CC (2003) Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem 278(38):36582-7
4)	Kim D, et al. (2006) Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans. Biochemistry 45(49):14772-80
5)	Collinson EJ, et al. (2011) The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes. J Biol Chem 286(3):2205-14