PWP1/YLR196W Protein Information

Standard Name	Pwp1p 1
Systematic Name	Ylr196wp
ORF Classification	Verified
Description	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily (1, 2)
Name Description	Periodic tryptophan (W) Protein 1

Experimental Data
Molecules/cell	43800 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	576
Molecular Weight (Da)	63,803
Isoelectric Point (pI)	4.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pwp1p (InterPro)
Physical Interactions	There are 101 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000532A2 \| P21304 MIPS: YLR196W NCBI: 131666 \| 172309 \| 544507 \| 6323225 \| NP_013297.1 GenBank/EMBL/DDBJ: DAA09515.1 \| M37578 \| U14913

Amino Acid Sequence (or in FASTA format)
1 MISATNWVPR GFSSEFPEKY VLDDEEVERI NQLAQLNLDD AKATLEEAEG 51 ESGVEDDAAT GSSNKLKDQL DIDDDLKEYN LEEYDDEEIA DNEGGKDVSM 101 FPGLSNDSDV KFHEGEKGED PYISLPNQED SQEEKQELQV YPSDNLVLAA 151 RTEDDVSYLD IYVYDDGAGF HSSDIPVEEG DEADPDVARG LVRDPALYVH 201 HDLMLPAFPL CVEWLDYKVG SNSEEAANYA AIGTFDPQIE IWNLDCVDKA 251 FPDMILGEPL DNSMVSLKSK KKKKKSKTGH ITTHHTDAVL SMAHNKYFRS 301 VLASTSADHT VKLWDLNSGN AARSLASIHS NKNVSSSEWH MLNGSILLTG 351 GYDSRVALTD VRISDESQMS KYWSAMAGEE IETVTFASEN IILCGTDSGN 401 VYSFDIRNNE NRKPVWTLKA HDAGISTLCS NKFIPGMMST GAMGEKTVKL 451 WKFPLDDATN TKGPSMVLSR DFDVGNVLTS SFAPDIEVAG TMVIGGVNKV 501 LKLWDVFTNR SVRKSFKSEL ENVQARAKEE AQKIGKSSRI ARKYTSNDNP 551 DTVITIDDQG EDEEEREGGD EHDDMA*

Amino Acid Sequence (or in FASTA format)

       1  MISATNWVPR GFSSEFPEKY VLDDEEVERI NQLAQLNLDD AKATLEEAEG
      51  ESGVEDDAAT GSSNKLKDQL DIDDDLKEYN LEEYDDEEIA DNEGGKDVSM
     101  FPGLSNDSDV KFHEGEKGED PYISLPNQED SQEEKQELQV YPSDNLVLAA
     151  RTEDDVSYLD IYVYDDGAGF HSSDIPVEEG DEADPDVARG LVRDPALYVH
     201  HDLMLPAFPL CVEWLDYKVG SNSEEAANYA AIGTFDPQIE IWNLDCVDKA
     251  FPDMILGEPL DNSMVSLKSK KKKKKSKTGH ITTHHTDAVL SMAHNKYFRS
     301  VLASTSADHT VKLWDLNSGN AARSLASIHS NKNVSSSEWH MLNGSILLTG
     351  GYDSRVALTD VRISDESQMS KYWSAMAGEE IETVTFASEN IILCGTDSGN
     401  VYSFDIRNNE NRKPVWTLKA HDAGISTLCS NKFIPGMMST GAMGEKTVKL
     451  WKFPLDDATN TKGPSMVLSR DFDVGNVLTS SFAPDIEVAG TMVIGGVNKV
     501  LKLWDVFTNR SVRKSFKSEL ENVQARAKEE AQKIGKSSRI ARKYTSNDNP
     551  DTVITIDDQG EDEEEREGGD EHDDMA*

external links for Pwp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pwp1p

1)	Duronio RJ, et al. (1992) Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Proteins 13(1):41-56
2)	Zhang W, et al. (2004) The functional landscape of mouse gene expression. J Biol 3(5):21
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41