NMT1/YLR195C Protein Information Help

Standard Name Nmt1p 1
Systematic Name Ylr195cp
Alias Cdc72p 2
ORF Classification Verified
Description N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction (1, 3, 4, 5)
Name Description N-Myristoyl Transferase 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 455
Molecular Weight (Da) 52,837
Isoelectric Point (pI) 7.42

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Nmt1p (InterPro)
Physical Interactions There are 13 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000130281 | P14743
MIPS: YLR195C
NCBI: 128399 | 172045 | 4139448 | 544511 | 6323224 | NP_013296.1 | NM_001182082.1
GenBank/EMBL/DDBJ: AAA34815.1 | AAB67436.1 | DAA09514.1 | M23726 | U14913
External Classifications EC: 2.3.1.97 [Glycylpeptide N-tetradecanoyltransferase]
Amino Acid Sequence (or in FASTA format)
       1  MSEEDKAKKL ENLLKLLQLN NDDTSKFTQE QKKAMKDHKF WRTQPVKDFD
      51  EKVVEEGPID KPKTPEDISD KPLPLLSSFE WCSIDVDNKK QLEDVFVLLN
     101  ENYVEDRDAG FRFNYTKEFF NWALKSPGWK KDWHIGVRVK ETQKLVAFIS
     151  AIPVTLGVRG KQVPSVEINF LCVHKQLRSK RLTPVLIKEI TRRVNKCDIW
     201  HALYTAGIVL PAPVSTCRYT HRPLNWKKLY EVDFTGLPDG HTEEDMIAEN
     251  ALPAKTKTAG LRKLKKEDID QVFELFKRYQ SRFELIQIFT KEEFEHNFIG
     301  EESLPLDKQV IFSYVVEQPD GKITDFFSFY SLPFTILNNT KYKDLGIGYL
     351  YYYATDADFQ FKDRFDPKAT KALKTRLCEL IYDACILAKN ANMDVFNALT
     401  SQDNTLFLDD LKFGPGDGFL NFYLFNYRAK PITGGLNPDN SNDIKRRSNV
     451  GVVML*                                                

external links for Nmt1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Aspergillus (AspGD) CYC2008 (complexes) MIPS YPL+
Candida (CGD) Complexome Pfam domains YeastGFP
YGOB GeneMANIA YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository
YOGY IMP

References cited on this page View Complete Literature Guide for Nmt1p
1) Duronio RJ, et al.  (1989) Disruption of the yeast N-myristoyl transferase gene causes recessive lethality. Science 243(4892):796-800
2) Reed SI, et al.  (1988) Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73. Cold Spring Harb Symp Quant Biol 53 Pt 2:621-7
3) Knoll LJ, et al.  (1992) Analysis of the compartmentalization of myristoyl-CoA:protein N-myristoyltransferase in Saccharomyces cerevisiae. J Biol Chem 267(8):5366-73
4) Stone DE, et al.  (1991) N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase. Genes Dev 5(11):1969-81
5) Towler DA, et al.  (1987) Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase. J Biol Chem 262(3):1030-6