MDL1/YLR188W Protein Information Help

Standard Name Mdl1p
Systematic Name Ylr188wp
ORF Classification Verified
Description Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress (1, 2, 3, 4)
Name Description MultiDrug resistance-Like 1
Experimental Data
Molecules/cell 1040 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 695
Molecular Weight (Da) 75,949
Isoelectric Point (pI) 10.61

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mdl1p (InterPro)
Transmembrane Domains There are 5 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012EE63 | P33310
MIPS: YLR188W
NCBI: 1346512 | 295584 | 577195 | 6323217 | NP_013289.1
GenBank/EMBL/DDBJ: DAA09507.1 | L16958 | U17246
External Classifications TC: 3.A.1.212 [The Mitochondrial Peptide Exporter (MPE) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MIVRMIRLCK GPKLLRSQFA SASALYSTKS LFKPPMYQKA EINLIIPHRK
      51  HFLLRSIRLQ SDIAQGKKST KPTLKLSNAN SKSSGFKDIK RLFVLSKPES
     101  KYIGLALLLI LISSSVSMAV PSVIGKLLDL ASESDGEDEE GSKSNKLYGF
     151  TKKQFFTALG AVFIIGAVAN ASRIIILKVT GERLVARLRT RTMKAALDQD
     201  ATFLDTNRVG DLISRLSSDA SIVAKSVTQN VSDGTRAIIQ GFVGFGMMSF
     251  LSWKLTCVMM ILAPPLGAMA LIYGRKIRNL SRQLQTSVGG LTKVAEEQLN
     301  ATRTIQAYGG EKNEVRRYAK EVRNVFHIGL KEAVTSGLFF GSTGLVGNTA
     351  MLSLLLVGTS MIQSGSMTVG ELSSFMMYAV YTGSSLFGLS SFYSELMKGA
     401  GAAARVFELN DRKPLIRPTI GKDPVSLAQK PIVFKNVSFT YPTRPKHQIF
     451  KDLNITIKPG EHVCAVGPSG SGKSTIASLL LRYYDVNSGS IEFGDEDIRN
     501  FNLRKYRRLI GYVQQEPLLF NGTILDNILY CIPPEIAEQD DRIRRAIGKA
     551  NCTKFLANFP DGLQTMVGAR GAQLSGGQKQ RIALARAFLL DPAVLILDEA
     601  TSALDSQSEE IVAKNLQRRV ERGFTTISIA HRLSTIKHST RVIVLGKHGS
     651  VVETGSFRDL IAIPNSELNA LLAEQQDEEG KGGVIDLDNS VAREV*

external links for Mdl1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome TCDB
YGOB GeneMANIA YeastRC Structure Prediction (Seattle)
YOGY


References cited on this page View Complete Literature Guide for Mdl1p
1) Dean M, et al.  (1994) Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily. Yeast 10(3):377-83
2) Young L, et al.  (2001) Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 291(5511):2135-8
3) Chloupkova M, et al.  (2003) MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J Mol Biol 331(1):155-65
4) Galluhn D and Langer T  (2004) Reversible assembly of the ATP-binding cassette transporter Mdl1 with the F1F0-ATP synthase in mitochondria. J Biol Chem 279(37):38338-45
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41