RKM5/YLR137W Protein Information

Standard Name	Rkm5p 1
Systematic Name	Ylr137wp
ORF Classification	Verified
Description	Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species (1, 2)
Name Description	Ribosomal lysine (K) Methyltransferase 5 1

Experimental Data
Molecules/cell	468 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	367
Molecular Weight (Da)	41,392
Isoelectric Point (pI)	6.26

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rkm5p (InterPro)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A172 \| Q12367 MIPS: YLR137W NCBI: 1256900 \| 1360555 \| 6323166 \| 74676588 \| 995703 \| NP_013238.1 GenBank/EMBL/DDBJ: DAA09448.1 \| U53881 \| X91258 \| Z73309

Amino Acid Sequence (or in FASTA format)
1 MAFKLWLLDE ETIYEHVFER YTQLEGQSGK LAQDLGIQDR RGGVLEITFE 51 PSGLEGGRKK KRVRRRNKAS SVEEDQNVAV DSYHVSVGQS ISSLRSSRDN 101 GNSTTGYVLW STTPFFINWL LYSTSAAPFR LGSQVEVTCG SSCEGHKLEL 151 PRLVDLTGAD RGKRGILELG AGISGILPVI LGNFVDTYVS TDQKGILNKL 201 KDNIMENLSQ LTRKRCISRS LRLELPTVEP VGDADITAAS LPSKSTLHLE 251 VAALDWEKIN LQDKKTHSLH PELSLIGETC SSVYVIAMDV IYNEYLIDPF 301 LKTLKQLKHW LQTTYNLQFH VLVGIHLRSQ EVTTLFLEKA IIEYDFTVYD 351 IVDQVIQESR FNFYLIT*

Amino Acid Sequence (or in FASTA format)

       1  MAFKLWLLDE ETIYEHVFER YTQLEGQSGK LAQDLGIQDR RGGVLEITFE
      51  PSGLEGGRKK KRVRRRNKAS SVEEDQNVAV DSYHVSVGQS ISSLRSSRDN
     101  GNSTTGYVLW STTPFFINWL LYSTSAAPFR LGSQVEVTCG SSCEGHKLEL
     151  PRLVDLTGAD RGKRGILELG AGISGILPVI LGNFVDTYVS TDQKGILNKL
     201  KDNIMENLSQ LTRKRCISRS LRLELPTVEP VGDADITAAS LPSKSTLHLE
     251  VAALDWEKIN LQDKKTHSLH PELSLIGETC SSVYVIAMDV IYNEYLIDPF
     301  LKTLKQLKHW LQTTYNLQFH VLVGIHLRSQ EVTTLFLEKA IIEYDFTVYD
     351  IVDQVIQESR FNFYLIT*

external links for Rkm5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rkm5p

1)	Webb KJ, et al. (2011) The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase. J Biol Chem 286(21):18405-13
2)	Petrossian TC and Clarke SG (2009) Multiple Motif Scanning to identify methyltransferases from the yeast proteome. Mol Cell Proteomics 8(7):1516-26
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41