MSL5/YLR116W Protein Information Help

Standard Name Msl5p 1
Systematic Name Ylr116wp
ORF Classification Verified
Description Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description Mud Synthetic-Lethal 1
Gene Product BBP 1
Experimental Data
Molecules/cell 4380 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 476
Molecular Weight (Da) 53,034
Isoelectric Point (pI) 10.49

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Msl5p (InterPro)
Physical Interactions There are 69 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006ABF6 | Q12186
MIPS: YLR116W
NCBI: 1256857 | 1297031 | 1360514 | 281500738 | 6323145 | 74645032 | NP_013217.1 | NM_001182003.1
GenBank/EMBL/DDBJ: AAB82363.1 | CAA61695.1 | CAA97683.1 | DAA09430.1 | U53877 | X89514 | Z73288
Amino Acid Sequence (or in FASTA format)
       1  MSFRRINSRY FENRKGSSME EKKAKVPPNV NLSLWRKNTV ESDVHRFNSL
      51  PSKISGALTR EQIYSYQVMF RIQEITIKLR TNDFVPPSRK NRSPSPPPVY
     101  DAQGKRTNTR EQRYRKKLED ERIKLVEIAL KTIPYFVPPD DYKRPTKFQD
     151  KYYIPVDQYP DVNFVGLLLG PRGRTLRKLQ EDSNCKIAIR GRGSVKEGKN
     201  ASDLPPGAMN FEDPLHCLII ADSEDKIQKG IKVCQNIVIK AVTSPEGQND
     251  LKRGQLRELA ELNGTLREDN RPCPICGLKD HKRYDCPNRK IPNIQGIVCK
     301  ICGQTGHFSR DCNSSSQRMS RFDRNATVNN SAPIQSNDVH YNSNTHPIQA
     351  PKRSRYDNNS TEPPLKFPAS SRYAPSPSPP ASHISRQAQN VTPTPPPGLT
     401  SSSFSSGVPG IAPPPLQSPP ESEQPKFSLP PPPGMTTVQS SIAPPPGLSG
     451  PPGFSNNMGN DINKPTPPGL QGPPGL*                         

external links for Msl5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Msl5p
1) Abovich N and Rosbash M  (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89(3):403-12
2) Rutz B and Seraphin B  (2000) A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing. EMBO J 19(8):1873-86
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41