AHP1/YLR109W Protein Information

Standard Name	Ahp1p
Systematic Name	Ylr109wp
ORF Classification	Verified
Description	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p (1, 2, 3)
Name Description	Alkyl HydroPeroxide reductase 1
Gene Product	cTPxIII

Experimental Data
Molecules/cell	16200 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	176
Molecular Weight (Da)	19,115
Isoelectric Point (pI)	4.87

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ahp1p (InterPro)
Physical Interactions	There are 51 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F945 \| P38013 MIPS: YLR109W NCBI: 1256872 \| 1297023 \| 1360500 \| 1709682 \| 383875703 \| 383875704 \| 383875705 \| 383875706 \| 383875707 \| 383875708 \| 383875709 \| 383875710 \| 383875711 \| 408536108 \| 6323138 \| NP_013210.1 GenBank/EMBL/DDBJ: DAA09425.1 \| U53878 \| X89514 \| Z73281
External Classifications	EC: 1.11.1.15 [Peroxiredoxin]

Amino Acid Sequence (or in FASTA format)
1 MSDLVNKKFP AGDYKFQYIA ISQSDADSES CKMPQTVEWS KLISENKKVI 51 ITGAPAAFSP TCTVSHIPGY INYLDELVKE KEVDQVIVVT VDNPFANQAW 101 AKSLGVKDTT HIKFASDPGC AFTKSIGFEL AVGDGVYWSG RWAMVVENGI 151 VTYAAKETNP GTDVTVSSVE SVLAHL*

Amino Acid Sequence (or in FASTA format)

       1  MSDLVNKKFP AGDYKFQYIA ISQSDADSES CKMPQTVEWS KLISENKKVI
      51  ITGAPAAFSP TCTVSHIPGY INYLDELVKE KEVDQVIVVT VDNPFANQAW
     101  AKSLGVKDTT HIKFASDPGC AFTKSIGFEL AVGDGVYWSG RWAMVVENGI
     151  VTYAAKETNP GTDVTVSSVE SVLAHL*

external links for Ahp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ahp1p

1)	Lee J, et al. (1999) A new antioxidant with alkyl hydroperoxide defense properties in yeast. J Biol Chem 274(8):4537-44
2)	Goehring AS, et al. (2003) Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Eukaryot Cell 2(5):930-6
3)	Trivelli X, et al. (2003) Characterization of the yeast peroxiredoxin Ahp1 in its reduced active and overoxidized inactive forms using NMR. Biochemistry 42(48):14139-49
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41