MDN1/YLR106C Protein Information Help

Standard Name Mdn1p 1
Systematic Name Ylr106cp
Alias Rea1p
ORF Classification Verified
Description Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus (1, 2, 3, 4)
Name Description MiDasiN 1
Experimental Data
Molecules/cell 538 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 4,910
Molecular Weight (Da) 559,302
Isoelectric Point (pI) 4.73

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mdn1p (InterPro)
Physical Interactions There are 101 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013C4B9 | Q12019
MIPS: YLR106C
NCBI: 1256854 | 1360494 | 24211972 | 6323135 | NP_013207.1
GenBank/EMBL/DDBJ: DAA09422.1 | U53876 | Z73278
Amino Acid Sequence (or in FASTA format)
       1  MSQDRILLDL DVVNQRLILF NSAFPSDAIE APFHFSNKES TSENLDNLAG
      51  TILHSRSITG HVFLYKHIFL EIVARWIKDS KKKDYVLVIE KLASIITIFP
     101  VAMPLIEDYL DKENDHFITI LQNPSTQKDS DMFKILLAYY RLLYHNKEVF
     151  ARFIQPDILY QLVDLLTKEQ ENQVVIFLAL KVLSLYLDMG EKTLNDMLDT
     201  YIKSRDSLLG HFEGDSGIDY SFLELNEAKR CANFSKLPSV PECFTIEKKS
     251  SYFIIEPQDL STKVASICGV IVPKVHTIHD KVFYPLTFVP THKTVSSLRQ
     301  LGRKIQNSTP IMLIGKAGSG KTFLINELSK YMGCHDSIVK IHLGEQTDAK
     351  LLIGTYTSGD KPGTFEWRAG VLATAVKEGR WVLIEDIDKA PTDVLSILLS
     401  LLEKRELTIP SRGETVKAAN GFQLISTVRI NEDHQKDSSN KIYNLNMIGM
     451  RIWNVIELEE PSEEDLTHIL AQKFPILTNL IPKLIDSYKN VKSIYMNTKF
     501  ISLNKGAHTR VVSVRDLIKL CERLDILFKN NGINKPDQLI QSSVYDSIFS
     551  EAADCFAGAI GEFKALEPII QAIGESLDIA SSRISLFLTQ HVPTLENLDD
     601  SIKIGRAVLL KEKLNIQKKS MNSTLFAFTN HSLRLMEQIS VCIQMTEPVL
     651  LVGETGTGKT TVVQQLAKML AKKLTVINVS QQTETGDLLG GYKPVNSKTV
     701  AVPIQENFET LFNATFSLKK NEKFHKMLHR CFNKNQWKNV VKLWNEAYKM
     751  AQSILKITNT ENENENAKKK KRRLNTHEKK LLLDKWADFN DSVKKFEAQS
     801  SSIENSFVFN FVEGSLVKTI RAGEWLLLDE VNLATADTLE SISDLLTEPD
     851  SRSILLSEKG DAEPIKAHPD FRIFACMNPA TDVGKRDLPM GIRSRFTEIY
     901  VHSPERDITD LLSIIDKYIG KYSVSDEWVG NDIAELYLEA KKLSDNNTIV
     951  DGSNQKPHFS IRTLTRTLLY VTDIIHIYGL RRSLYDGFCM SFLTLLDQKS
    1001  EAILKPVIEK FTLGRLKNVK SIMSQTPPSP GPDYVQFKHY WMKKGPNTIQ
    1051  EQAHYIITPF VEKNMMNLVR ATSGKRFPVL IQGPTSSGKT SMIKYLADIT
    1101  GHKFVRINNH EHTDLQEYLG TYVTDDTGKL SFKEGVLVEA LRKGYWIVLD
    1151  ELNLAPTDVL EALNRLLDDN RELFIPETQE VVHPHPDFLL FATQNPPGIY
    1201  GGRKILSRAF RNRFLELHFD DIPQDELEII LRERCQIAPS YAKKIVEVYR
    1251  QLSIERSASR LFEQKNSFAT LRDLFRWALR DAVGYEQLAA SGYMLLAERC
    1301  RTPQEKVTVK KTLEKVMKVK LDMDQYYASL EDKSLEAIGS VTWTKGMRRL
    1351  SVLVSSCLKN KEPVLLVGET GCGKTTICQL LAQFMGRELI TLNAHQNTET
    1401  GDILGAQRPV RNRSEIQYKL IKSLKTALNI ANDQDVDLKE LLQLYSKSDN
    1451  KNIAEDVQLE IQKLRDSLNV LFEWSDGPLI QAMRTGNFFL LDEISLADDS
    1501  VLERLNSVLE PERSLLLAEQ GSSDSLVTAS ENFQFFATMN PGGDYGKKEL
    1551  SPALRNRFTE IWVPSMEDFN DVNMIVSSRL LEDLKDLANP IVKFSEWFGK
    1601  KLGGGNATSG VISLRDILAW VEFINKVFPK IQNKSTALIQ GASMVFIDAL
    1651  GTNNTAYLAE NENDLKSLRT ECIIQLLKLC GDDLELQQIE TNEIIVTQDE
    1701  LQVGMFKIPR FPDAQSSSFN LTAPTTASNL VRVVRAMQVH KPILLEGSPG
    1751  VGKTSLITAL ANITGNKLTR INLSEQTDLV DLFGADAPGE RSGEFLWHDA
    1801  PFLRAMKKGE WVLLDEMNLA SQSVLEGLNA CLDHRGEAYI PELDISFSCH
    1851  PNFLVFAAQN PQYQGGGRKG LPKSFVNRFS VVFIDMLTSD DLLLIAKHLY
    1901  PSIEPDIIAK MIKLMSTLED QVCKRKLWGN SGSPWEFNLR DTLRWLKLLN
    1951  QYSICEDVDV FDFVDIIVKQ RFRTISDKNK AQLLIEDIFG KFSTKENFFK
    2001  LTEDYVQINN EVALRNPHYR YPITQNLFPL ECNVAVYESV LKAINNNWPL
    2051  VLVGPSNSGK TETIRFLASI LGPRVDVFSM NSDIDSMDIL GGYEQVDLTR
    2101  QISYITEELT NIVREIISMN MKLSPNATAI MEGLNLLKYL LNNIVTPEKF
    2151  QDFRNRFNRF FSHLEGHPLL KTMSMNIEKM TEIITKEASV KFEWFDGMLV
    2201  KAVEKGHWLI LDNANLCSPS VLDRLNSLLE IDGSLLINEC SQEDGQPRVL
    2251  KPHPNFRLFL TMDPKYGELS RAMRNRGVEI YIDELHSRST AFDRLTLGFE
    2301  LGENIDFVSI DDGIKKIKLN EPDMSIPLKH YVPSYLSRPC IFAQVHDILL
    2351  LSDEEPIEES LAAVIPISHL GEVGKWANNV LNCTEYSEKK IAERLYVFIT
    2401  FLTDMGVLEK INNLYKPANL KFQKALGLHD KQLTEETVSL TLNEYVLPTV
    2451  SKYSDKIKSP ESLYLLSSLR LLLNSLNALK LINEKSTHGK IDELTYIELS
    2501  AAAFNGRHLK NIPRIPIFCI LYNILTVMSE NLKTESLFCG SNQYQYYWDL
    2551  LVIVIAALET AVTKDEARLR VYKELIDSWI ASVKSKSDIE ITPFLNINLE
    2601  FTDVLQLSRG HSITLLWDIF RKNYPTTSNS WLAFEKLINL SEKFDKVRLL
    2651  QFSESYNSIK DLMDVFRLLN DDVLNNKLSE FNLLLSKLED GINELELISN
    2701  KFLNKRKHYF ADEFDNLIRY TFSVDTAELI KELAPASSLA TQKLTKLITN
    2751  KYNYPPIFDV LWTEKNAKLT SFTSTIFSSQ FLEDVVRKSN NLKSFSGNQI
    2801  KQSISDAELL LSSTIKCSPN LLKSQMEYYK NMLLSWLRKV IDIHVGGDCL
    2851  KLTLKELCSL IEEKTASETR VTFAEYIFPA LDLAESSKSL EELGEAWITF
    2901  GTGLLLLFVP DSPYDPAIHD YVLYDLFLKT KTFSQNLMKS WRNVRKVISG
    2951  DEEIFTEKLI NTISDDDAPQ SPRVYRTGMS IDSLFDEWMA FLSSTMSSRQ
    3001  IKELVSSYKC NSDQSDRRLE MLQQNSAHFL NRLESGYSKF ADLNDILAGY
    3051  IYSINFGFDL LKLQKSKDRA SFQISPLWSM DPINISCAEN VLSAYHELSR
    3101  FFKKGDMEDT SIEKVLMYFL TLFKFHKRDT NLLEIFEAAL YTLYSRWSVR
    3151  RFRQEQEENE KSNMFKFNDN SDDYEADFRK LFPDYEDTAL VTNEKDISSP
    3201  ENLDDIYFKL ADTYISVFDK DHDANFSSEL KSGAIITTIL SEDLKNTRIE
    3251  ELKSGSLSAV INTLDAETQS FKNTEVFGNI DFYHDFSIPE FQKAGDIIET
    3301  VLKSVLKLLK QWPEHATLKE LYRVSQEFLN YPIKTPLARQ LQKIEQIYTY
    3351  LAEWEKYASS EVSLNNTVKL ITDLIVSWRK LELRTWKGLF NSEDAKTRKS
    3401  IGKWWFYLYE SIVISNFVSE KKETAPNATL LVSSLNLFFS KSTLGEFNAR
    3451  LDLVKAFYKH IQLIGLRSSK IAGLLHNTIK FYYQFKPLID ERITNGKKSL
    3501  EKEIDDIILL ASWKDVNVDA LKQSSRKSHN NLYKIVRKYR DLLNGDAKTI
    3551  IEAGLLYSNE NKLKLPTLKQ HFYEDPNLEA SKNLVKEIST WSMRAAPLRN
    3601  IDTVASNMDS YLEKISSQEF PNFADLASDF YAEAERLRKE TPNVYTKENK
    3651  KRLAYLKTQK SKLLGDALKE LRRIGLKVNF REDIQKVQSS TTTILANIAP
    3701  FNNEYLNSSD AFFFKILDLL PKLRSAASNP SDDIPVAAIE RGMALAQSLM
    3751  FSLITVRHPL SEFTNDYCKI NGMMLDLEHF TCLKGDIVHS SLKANVDNVR
    3801  LFEKWLPSLL DYAAQTLSVI SKYSATSEQQ KILLDAKSTL SSFFVHFNSS
    3851  RIFDSSFIES YSRFELFINE LLKKLENAKE TGNAFVFDII IEWIKANKGG
    3901  PIKKEQKRGP SVEDVEQAFR RTFTSIILSF QKVIGDGIES ISETDDNWLS
    3951  ASFKKVMVNV KLLRSSVVSK NIETALSLLK DFDFTTTESI YVKSVISFTL
    4001  PVITRYYNAM TVVLERSRIY YTNTSRGMYI LSTILHSLAK NGFCSPQPPS
    4051  EEVDDKNLQE GTGLGDGEGA QNNNKDVEQD EDLTEDAQNE NKEQQDKDER
    4101  DDENEDDAVE MEGDMAGELE DLSNGEENDD EDTDSEEEEL DEEIDDLNED
    4151  DPNAIDDKMW DDKASDNSKE KDTDQNLDGK NQEEDVQAAE NDEQQRDNKE
    4201  GGDEDPNAPE DGDEEIENDE NAEEENDVGE QEDEVKDEEG EDLEANVPEI
    4251  ETLDLPEDMN LDSEHEESDE DVDMSDGMPD DLNKEEVGNE DEEVKQESGI
    4301  ESDNENDEPG PEEDAGETET ALDEEEGAEE DVDMTNDEGK EDEENGPEEQ
    4351  AMSDEEELKQ DAAMEENKEK GGEQNTEGLD GVEEKADTED IDQEAAVQQD
    4401  SGSKGAGADA TDTQEQDDVG GSGTTQNTYE EDQEDVTKNN EESREEATAA
    4451  LKQLGDSMKE YHRRRQDIKE AQTNGEEDEN LEKNNERPDE FEHVEGANTE
    4501  TDTQALGSAT QDQLQTIDED MAIDDDREEQ EVDQKELVED ADDEKMDIDE
    4551  EEMLSDIDAH DANNDVDSKK SGFIGKRKSE EDFENELSNE HFSADQEDDS
    4601  EIQSLIENIE DNPPDASASL TPERSLEESR ELWHKSEIST ADLVSRLGEQ
    4651  LRLILEPTLA TKLKGDYKTG KRLNMKRIIP YIASQFRKDK IWLRRTKPSK
    4701  RQYQIMIALD DSKSMSESKC VKLAFDSLCL VSKTLTQLEA GGLSIVKFGE
    4751  NIKEVHSFDQ QFSNESGARA FQWFGFQETK TDVKKLVAES TKIFERARAM
    4801  VHNDQWQLEI VISDGICEDH ETIQKLVRRA RENKIMLVFV IIDGITSNES
    4851  ILDMSQVNYI PDQYGNPQLK ITKYLDTFPF EFYVVVHDIS ELPEMLSLIL
    4901  RQYFTDLASS *                                          

external links for Mdn1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome

YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Mdn1p
1) Garbarino J and Gibbons I  (2002) Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. BMC Genomics 3(1):18
2) Nissan TA, et al.  (2004) A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol Cell 15(2):295-301
3) Ulbrich C, et al.  (2009) Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits. Cell 138(5):911-22
4) Bassler J, et al.  (2010) The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly. Mol Cell 38(5):712-21
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41