GAA1/YLR088W Protein Information

Standard Name	Gaa1p 1
Systematic Name	Ylr088wp
Alias	End2p 2
ORF Classification	Verified
Description	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER (3)
Name Description	GPI Anchor Attachment 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	614
Molecular Weight (Da)	69,220
Isoelectric Point (pI)	6.21

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gaa1p (InterPro)
Transmembrane Domains	There are 6 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C70 \| P39012 MIPS: YLR088W NCBI: 1256890 \| 1360459 \| 495142 \| 6323117 \| 729417 \| NP_013189.1 GenBank/EMBL/DDBJ: DAA09404.1 \| U53880 \| X79409 \| Z73260

Amino Acid Sequence (or in FASTA format)
1 MALLEKLHRR IVDMGLVPRI IALLPVISML CALFGFISIA ILPMDGQYRR 51 TYISENALMP SQAYSYFRES EWNILRGYRS QIKEMVNMTS MERNNLMGSW 101 LQEFGTKTAI YENEQYGETL YGVMHAPRGD GTEAMVLAVP WFNSDDEFNI 151 GGAALGVSLA RFFSRWPVWS KNIIVVFSEN PRAALRSWVE AYHTSLDLTG 201 GSIEAAVVLD YSSTEDFFEY VEISYDGLNG ELPNLDLVNI AISITEHEGM 251 KVSLHGLPSD QLTNNNFWSR LKILCLGIRD WALSGVKKPH GNEAFSGWRI 301 QSVTLKAHGN SGHDITTFGR IPEAMFRSIN NLLEKFHQSF FFYLLLAPRQ 351 FVSISSYLPS AVALSIAFAI SSLNAFINNA YANISLFSEY NLVALLVWFV 401 SLVISFVVSQ AFLLIPSSGL LMTISMASCF LPLILSRKIH ISEPLSYRLK 451 NVAFLYFSLV STSLLMINFA MALLIGTLAF PMTFVKTIVE SSSEHEVTTQ 501 SSNPIKTEPK DEIELVENHM DTTPATPQQQ KQKLKNLVLL ILTNPFISIT 551 LFGLFFDDEF HGFDIINKLV SAWLDLKCWS WFVLCIGWLP CWLLILASSF 601 ESKSVVVRSK EKQS*

Amino Acid Sequence (or in FASTA format)

       1  MALLEKLHRR IVDMGLVPRI IALLPVISML CALFGFISIA ILPMDGQYRR
      51  TYISENALMP SQAYSYFRES EWNILRGYRS QIKEMVNMTS MERNNLMGSW
     101  LQEFGTKTAI YENEQYGETL YGVMHAPRGD GTEAMVLAVP WFNSDDEFNI
     151  GGAALGVSLA RFFSRWPVWS KNIIVVFSEN PRAALRSWVE AYHTSLDLTG
     201  GSIEAAVVLD YSSTEDFFEY VEISYDGLNG ELPNLDLVNI AISITEHEGM
     251  KVSLHGLPSD QLTNNNFWSR LKILCLGIRD WALSGVKKPH GNEAFSGWRI
     301  QSVTLKAHGN SGHDITTFGR IPEAMFRSIN NLLEKFHQSF FFYLLLAPRQ
     351  FVSISSYLPS AVALSIAFAI SSLNAFINNA YANISLFSEY NLVALLVWFV
     401  SLVISFVVSQ AFLLIPSSGL LMTISMASCF LPLILSRKIH ISEPLSYRLK
     451  NVAFLYFSLV STSLLMINFA MALLIGTLAF PMTFVKTIVE SSSEHEVTTQ
     501  SSNPIKTEPK DEIELVENHM DTTPATPQQQ KQKLKNLVLL ILTNPFISIT
     551  LFGLFFDDEF HGFDIINKLV SAWLDLKCWS WFVLCIGWLP CWLLILASSF
     601  ESKSVVVRSK EKQS*

external links for Gaa1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Gaa1p

1)	Hamburger D, et al. (1995) Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins. J Cell Biol 129(3):629-39
2)	Chvatchko Y, et al. (1986) Two yeast mutants defective in endocytosis are defective in pheromone response. Cell 46(3):355-64
3)	Fraering P, et al. (2001) The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Mol Biol Cell 12(10):3295-306