GAL2/YLR081W Protein Information

Standard Name	Gal2p 1
Systematic Name	Ylr081wp
ORF Classification	Verified
Description	Galactose permease, required for utilization of galactose; also able to transport glucose (2, 3, 4)
Name Description	GALactose metabolism

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	574
Molecular Weight (Da)	63,625
Isoelectric Point (pI)	7.21

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gal2p (InterPro)
Transmembrane Domains	There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012B06F \| P13181 MIPS: YLR081W NCBI: 1256883 \| 1360445 \| 171552 \| 171554 \| 2204268 \| 3915704 \| 6323110 \| NP_013182.1 GenBank/EMBL/DDBJ: DAA09397.1 \| M68547 \| M81879 \| U53880 \| Z73253 \| Z73254
External Classifications	TC: 2.A.1.1 [The Sugar Porter (SP) Family]

Amino Acid Sequence (or in FASTA format)
1 MAVEENNMPV VSQQPQAGED VISSLSKDSH LSAQSQKYSN DELKAGESGS 51 EGSQSVPIEI PKKPMSEYVT VSLLCLCVAF GGFMFGWDTG TISGFVVQTD 101 FLRRFGMKHK DGTHYLSNVR TGLIVAIFNI GCAFGGIILS KGGDMYGRKK 151 GLSIVVSVYI VGIIIQIASI NKWYQYFIGR IISGLGVGGI AVLCPMLISE 201 IAPKHLRGTL VSCYQLMITA GIFLGYCTNY GTKSYSNSVQ WRVPLGLCFA 251 WSLFMIGALT LVPESPRYLC EVNKVEDAKR SIAKSNKVSP EDPAVQAELD 301 LIMAGIEAEK LAGNASWGEL FSTKTKVFQR LLMGVFVQMF QQLTGNNYFF 351 YYGTVIFKSV GLDDSFETSI VIGVVNFAST FFSLWTVENL GHRKCLLLGA 401 ATMMACMVIY ASVGVTRLYP HGKSQPSSKG AGNCMIVFTC FYIFCYATTW 451 APVAWVITAE SFPLRVKSKC MALASASNWV WGFLIAFFTP FITSAINFYY 501 GYVFMGCLVA MFFYVFFFVP ETKGLSLEEI QELWEEGVLP WKSEGWIPSS 551 RRGNNYDLED LQHDDKPWYK AMLE*

Amino Acid Sequence (or in FASTA format)

       1  MAVEENNMPV VSQQPQAGED VISSLSKDSH LSAQSQKYSN DELKAGESGS
      51  EGSQSVPIEI PKKPMSEYVT VSLLCLCVAF GGFMFGWDTG TISGFVVQTD
     101  FLRRFGMKHK DGTHYLSNVR TGLIVAIFNI GCAFGGIILS KGGDMYGRKK
     151  GLSIVVSVYI VGIIIQIASI NKWYQYFIGR IISGLGVGGI AVLCPMLISE
     201  IAPKHLRGTL VSCYQLMITA GIFLGYCTNY GTKSYSNSVQ WRVPLGLCFA
     251  WSLFMIGALT LVPESPRYLC EVNKVEDAKR SIAKSNKVSP EDPAVQAELD
     301  LIMAGIEAEK LAGNASWGEL FSTKTKVFQR LLMGVFVQMF QQLTGNNYFF
     351  YYGTVIFKSV GLDDSFETSI VIGVVNFAST FFSLWTVENL GHRKCLLLGA
     401  ATMMACMVIY ASVGVTRLYP HGKSQPSSKG AGNCMIVFTC FYIFCYATTW
     451  APVAWVITAE SFPLRVKSKC MALASASNWV WGFLIAFFTP FITSAINFYY
     501  GYVFMGCLVA MFFYVFFFVP ETKGLSLEEI QELWEEGVLP WKSEGWIPSS
     551  RRGNNYDLED LQHDDKPWYK AMLE*

external links for Gal2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Gal2p

1)	DOUGLAS HC and CONDIE F (1954) The genetic control of galactose utilization in Saccharomyces. J Bacteriol 68(6):662-70
2)	Rodriguez C and Flores C (2000) Mutations in GAL2 or GAL4 alleviate catabolite repression produced by galactose in Saccharomyces cerevisiae. Enzyme Microb Technol 26(9-10):748-755
3)	Kasahara T and Kasahara M (2000) Three aromatic amino acid residues critical for galactose transport in yeast Gal2 transporter. J Biol Chem 275(6):4422-8
4)	Maier A, et al. (2002) Characterisation of glucose transport in Saccharomyces cerevisiae with plasma membrane vesicles (countertransport) and intact cells (initial uptake) with single Hxt1, Hxt2, Hxt3, Hxt4, Hxt6, Hxt7 or Gal2 transporters. FEMS Yeast Res 2(4):539-50