EMP46/YLR080W Protein Information

Standard Name	Emp46p
Systematic Name	Ylr080wp
ORF Classification	Verified
Description	Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication (1, 2, 3)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	444
Molecular Weight (Da)	50,947
Isoelectric Point (pI)	9.95

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Emp46p (InterPro)
Transmembrane Domains	There are 2 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C610 \| Q12396 MIPS: YLR080W NCBI: 1256882 \| 1360443 \| 6323109 \| 74676594 \| 88191981 \| 88191982 \| 88191983 \| 88191984 \| 88191985 \| 88191986 \| NP_013181.1 GenBank/EMBL/DDBJ: DAA09396.1 \| U53880 \| Z73252

Amino Acid Sequence (or in FASTA format)
1 MTTRKTASSL QLLGKITGTK AGTKQKKMNF INGLIWLYMC VWMVHGKVTQ 51 KDELKWNKGY SLPNLLEVTD QQKELSQWTL GDKVKLEEGR FVLTPGKNTK 101 GSLWLKPEYS IKDAMTIEWT FRSFGFRGST KGGLAFWLKQ GNEGDSTELF 151 GGSSKKFNGL MILLRLDDKL GESVTAYLND GTKDLDIESS PYFASCLFQY 201 QDSMVPSTLR LTYNPLDNHL LKLQMDNRVC FQTRKVKFMG SSPFRIGTSA 251 INDASKESFE ILKMKLYDGV IEDSLIPNVN PMGQPRVVTK VINSQTGEES 301 FREKMPFSDK EESITSNELF EKMNKLEGKI MANDIDPLLR KMNKIVENER 351 ELIQRLRPLL DLKKTAISDD SFQDFLSMNA NLDRLIKEQE KIRQDAKLYG 401 KQTKGHDEIF SKISVWLALL IFIMITLAYY MFRINQDIKK VKLL*

Amino Acid Sequence (or in FASTA format)

       1  MTTRKTASSL QLLGKITGTK AGTKQKKMNF INGLIWLYMC VWMVHGKVTQ
      51  KDELKWNKGY SLPNLLEVTD QQKELSQWTL GDKVKLEEGR FVLTPGKNTK
     101  GSLWLKPEYS IKDAMTIEWT FRSFGFRGST KGGLAFWLKQ GNEGDSTELF
     151  GGSSKKFNGL MILLRLDDKL GESVTAYLND GTKDLDIESS PYFASCLFQY
     201  QDSMVPSTLR LTYNPLDNHL LKLQMDNRVC FQTRKVKFMG SSPFRIGTSA
     251  INDASKESFE ILKMKLYDGV IEDSLIPNVN PMGQPRVVTK VINSQTGEES
     301  FREKMPFSDK EESITSNELF EKMNKLEGKI MANDIDPLLR KMNKIVENER
     351  ELIQRLRPLL DLKKTAISDD SFQDFLSMNA NLDRLIKEQE KIRQDAKLYG
     401  KQTKGHDEIF SKISVWLALL IFIMITLAYY MFRINQDIKK VKLL*

external links for Emp46p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Emp46p

1)	Otte S, et al. (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18
2)	Sato K and Nakano A (2002) Emp47p and its close homolog Emp46p have a tyrosine-containing endoplasmic reticulum exit signal and function in glycoprotein secretion in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2518-32
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61