RGR1/YLR071C Protein Information Help

Standard Name Rgr1p
Systematic Name Ylr071cp
Alias Med14p 1
ORF Classification Verified
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation (2, 3, 4)
Name Description Resistant to Glucose Repression 5
Experimental Data
Molecules/cell 319 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,082
Molecular Weight (Da) 123,357
Isoelectric Point (pI) 9.3

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rgr1p (InterPro)
Physical Interactions There are 197 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F2B | P19263
MIPS: YLR071C
NCBI: 1360426 | 218472 | 31077171 | 51013335 | 6323100 | NP_013172.1 | NM_001181958.1
GenBank/EMBL/DDBJ: DAA09388.1 | AY692942 | D90051 | Z73243
Amino Acid Sequence (or in FASTA format)
 
       1  MTTTIGSPQM LANEERLSNE MHALKNRSEQ NGQEQQGPVK NTQLHGPSAT
      51  DPETTATQKE SLEMVPKDTS AATMTSAPPP ALPHVEINQV SLALVIRNLT
     101  VFTMKELAQY MKTNVHTQAN EPNSAKKIRF LQLIIFLRTQ FLKLYVLVKW
     151  TRTIKQNNFH VLIDLLNWFR TTNMNVNNCI WALKSSLNSM TNAKLPNVDL
     201  VTALEVLSLG RPNLPTHNFK LSGVSNSMDM VDGMAKVPIG LILQRLKDLN
     251  LTVSIKIALM NIPKPLNSYH IKNGRIYFTV PNEFEIQLST VNRQSPLFFV
     301  DLKLLFNTEA EQTVSAVTEA TSTNGDSENN EENSSSNGNN LPLNKPRLEK
     351  LINEILLKSN DPLLSLYNFL HKYVLTLQLY MVHREFLKLA NGGKFSKSNL
     401  IHNYDSKKST ITVRYWLNGK MDSKGKITIG IQRTTESLIL KWDNQSASRA
     451  KNMPVIYNNI VSNIEGILDE IMFNHARIIR SELLARDIFQ EDEENSDVLL
     501  FQLPTTCVSM APIQLKIDLL SGQFYFRNPT PLLSNYASKI NRAEGPEELA
     551  RILQQLKLDK IIHVLTTMFE NTGWSCSRII KIDKPIRTQV NTGGESVVKK
     601  EDNKYAIAGN STTNSDVSLL LQRDLFIRLP HWPLNWYLIL SIISSKTSCV
     651  VEKRIGKIVS QRGKWNLKYL DNSNVMTVKL ESITYQKIMI LQRTILNRII
     701  NHMLIDSLNQ LEIRNKICSS EMINEQKLPQ YIIQGSNTND NISIITLELE
     751  SFLEGSKALN SILESSMFLR IDYSNSQIRL YAKFKRNTMM IQCQIDKLYI
     801  HFVQEEPLAF YLEESFTNLG IIVQYLTKFR QKLMQLVVLT DVVERLHKNF
     851  ESENFKIIAL QPNEISFKYL SNNDEDDKDC TIKISTNDDS IKNLTVQLSP
     901  SNPQHIIQPF LDNSKMDYHF IFSYLQFTSS LFKALKVILN ERGGKFHESG
     951  SQYSTMVNIG LHNLNEYQIV YYNPQAGTKI TICIELKTVL HNGRDKIQFH
    1001  IHFADVAHIT TKSPAYPMMH QVRNQVFMLD TKRLGTPESV KPANASHAIR
    1051  LGNGVACDPS EIEPILMEIH NILKVDSNSS SS*

external links for Rgr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rgr1p
1) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
2) Sakai A, et al.  (1990) Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae. Mol Cell Biol 10(8):4130-8
3) Myers LC, et al.  (1998) The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev 12(1):45-54
4) Li Y, et al.  (1995) Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A 92(24):10864-8
5) Sakai A, et al.  (1988) Isolation and characterization of mutants which show an oversecretion phenotype in Saccharomyces cerevisiae. Genetics 119(3):499-506
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41