XYL2/YLR070C Protein Information

Standard Name	Xyl2p 1
Systematic Name	Ylr070cp
ORF Classification	Verified
Description	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect (1, 2, 3)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	356
Molecular Weight (Da)	38,600
Isoelectric Point (pI)	6.08

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Xyl2p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006AFB6 \| Q07993 MIPS: YLR070C NCBI: 1360424 \| 6323099 \| 74655020 \| NP_013171.1 \| NM_001181957.1 GenBank/EMBL/DDBJ: DAA09387.1 \| Z73242
External Classifications	EC: 1.1.1.9 [D-xylulose reductase]

Amino Acid Sequence (or in FASTA format)
1 MTDLTTQEAI VLERPGKITL TNVSIPKISD PNEVIIQIKA TGICGSDIHY 51 YTHGRIANYV VESPMVLGHE SSGIVALIGE NVKTLKVGDR VALEPGIPDR 101 FSPEMKEGRY NLDPNLKFAA TPPFDGTLTK YYKTMKDFVY KLPDDVSFEE 151 GALIEPLSVA IHANKLAKIK FGARCVVFGA GPIGLLAGKV ASVFGAADVV 201 FVDLLENKLE TARQFGATHI VNSGDLPHGV TVDSVIKKAI GKKGADVVFE 251 CSGAEPCVRA GIEVCKAGGT IVQVGMGQEE IQFPISIIPT KELTFQGCFR 301 YCQGDYSDSI ELVSSRKLSL KPFITHRYSF KDAVEAFEET SHHPLNNIKT 351 IIEGPE*

Amino Acid Sequence (or in FASTA format)

       1  MTDLTTQEAI VLERPGKITL TNVSIPKISD PNEVIIQIKA TGICGSDIHY
      51  YTHGRIANYV VESPMVLGHE SSGIVALIGE NVKTLKVGDR VALEPGIPDR
     101  FSPEMKEGRY NLDPNLKFAA TPPFDGTLTK YYKTMKDFVY KLPDDVSFEE
     151  GALIEPLSVA IHANKLAKIK FGARCVVFGA GPIGLLAGKV ASVFGAADVV
     201  FVDLLENKLE TARQFGATHI VNSGDLPHGV TVDSVIKKAI GKKGADVVFE
     251  CSGAEPCVRA GIEVCKAGGT IVQVGMGQEE IQFPISIIPT KELTFQGCFR
     301  YCQGDYSDSI ELVSSRKLSL KPFITHRYSF KDAVEAFEET SHHPLNNIKT
     351  IIEGPE*

external links for Xyl2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Xyl2p

1)	Richard P, et al. (1999) Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase. FEBS Lett 457(1):135-8
2)	Toivari MH, et al. (2004) Endogenous xylose pathway in Saccharomyces cerevisiae. Appl Environ Microbiol 70(6):3681-6
3)	de Groot PW, et al. (2001) A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae. Comp Funct Genomics 2(3):124-42