REX2/YLR059C Protein Information

Standard Name	Rex2p 1
Systematic Name	Ylr059cp
Alias	Ynt20p 2
ORF Classification	Verified
Description	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease (1, 2)
Name Description	Rna EXonuclease 1

Experimental Data
Molecules/cell	1730 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	269
Molecular Weight (Da)	30,870
Isoelectric Point (pI)	7.05

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rex2p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000130E93 \| P54964 MIPS: YLR059C NCBI: 1019712 \| 1181280 \| 1360404 \| 1730818 \| 51013461 \| 6323088 \| NP_013160.1 GenBank/EMBL/DDBJ: DAA09377.1 \| AY693005 \| L47977 \| X94607 \| Z73231
External Classifications	EC: 3.1.-.- [Hydrolases acting on ester bonds ]

Amino Acid Sequence (or in FASTA format)
1 MKWLLFPARI VARTRPNLFS LYRRSVSQYL RPRTIQNLQS MAQTPELKTK 51 LFKPLVWIDC EMTGLDHVND RIIEICCIIT DGHLAPVKAA DGQGDSHYES 101 VIHYGPEVMN KMNEWCIEHH GNSGLTAKVL ASEKTLAQVE DELLEYIQRY 151 IPDKNVGVLA GNSVHMDRLF MVREFPKVID HLFYRIVDVS SIMEVARRHN 201 PALQARNPKK EAAHTAYSDI KESIAQLQWY MDNYLKPPQE TESVESIGSE 251 QPESPSSSTS SLKRQRTDF*

Amino Acid Sequence (or in FASTA format)

       1  MKWLLFPARI VARTRPNLFS LYRRSVSQYL RPRTIQNLQS MAQTPELKTK
      51  LFKPLVWIDC EMTGLDHVND RIIEICCIIT DGHLAPVKAA DGQGDSHYES
     101  VIHYGPEVMN KMNEWCIEHH GNSGLTAKVL ASEKTLAQVE DELLEYIQRY
     151  IPDKNVGVLA GNSVHMDRLF MVREFPKVID HLFYRIVDVS SIMEVARRHN
     201  PALQARNPKK EAAHTAYSDI KESIAQLQWY MDNYLKPPQE TESVESIGSE
     251  QPESPSSSTS SLKRQRTDF*

external links for Rex2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rex2p

1)	van Hoof A, et al. (2000) Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. EMBO J 19(6):1357-65
2)	Hanekamp T and Thorsness PE (1999) YNT20, a bypass suppressor of yme1 yme2, encodes a putative 3'-5' exonuclease localized in mitochondria of Saccharomyces cerevisiae. Curr Genet 34(6):438-48
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41