ERG3/YLR056W Protein Information Help

Standard Name Erg3p
Systematic Name Ylr056wp
Alias Syr1p , Pso6p 1
ORF Classification Verified
Description C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase (2, 3, 4, 5, 6)
Name Description ERGosterol biosynthesis
Experimental Data
Molecules/cell 36200 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 365
Molecular Weight (Da) 42,730
Isoelectric Point (pI) 7.73

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Erg3p (InterPro)
Transmembrane Domains There are 3 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 41 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012A146 | P32353
MIPS: YLR056W
NCBI: 1181277 | 1360398 | 171475 | 171477 | 2143190 | 233331 | 416963 | 51013443 | 6323085 | NP_013157.1
GenBank/EMBL/DDBJ: DAA09374.1 | AY692996 | D14299 | M62623 | M64989 | S46162 | X94607 | Z73228
External Classifications EC: 1.3.3.- [Oxidoreductases, Acting on the CH-CH group of donors, With oxygen as acceptor]
Amino Acid Sequence (or in FASTA format)
 
       1  MDLVLEVADH YVLDDLYAKV LPASLAANIP VKWQKLLGLN SGFSNSTILQ
      51  ETLNSKNAVK ECRRFYGQVP FLFDMSTTSF ASLLPRSSIL REFLSLWVIV
     101  TIFGLLLYLF TASLSYVFVF DKSIFNHPRY LKNQMAMEIK LAVSAIPWMS
     151  MLTVPWFVME LNGHSKLYMK IDYENHGVRK LIIEYFTFIF FTDCGVYLAH
     201  RWLHWPRVYR ALHKPHHKWL VCTPFASHSF HPVDGFLQSI SYHIYPLILP
     251  LHKVSYLILF TFVNFWTVMI HDGQYLSNNP AVNGTACHTV HHLYFNYNYG
     301  QFTTLWDRLG GSYRRPDDSL FDPKLRDAKE TWDAQVKEVE HFIKEVEGDD
     351  NDRIYENDPN TKKNN*

external links for Erg3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Erg3p
1) Brendel M and Henriques JA  (2001) The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism. Mutat Res 489(1):79-96
2) Lees ND, et al.  (1995) Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. Lipids 30(3):221-6
3) Parks LW, et al.  (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30
4) Arthington BA, et al.  (1991) Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102(1):39-44
5) Paltauf F, et al.  (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
6) Jaenicke LA, et al.  (2011) Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum. Mol Biol Cell 22(16):2937-45
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41