SPT8/YLR055C Protein Information Help

Standard Name Spt8p
Systematic Name Ylr055cp
ORF Classification Verified
Description Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters (1, 2)
Name Description SuPpressor of Ty
Experimental Data
Molecules/cell 8430 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 602
Molecular Weight (Da) 66,189
Isoelectric Point (pI) 4.12

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Spt8p (InterPro)
Physical Interactions There are 234 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000005312B | P38915
MIPS: YLR055C
NCBI: 1181276 | 1360396 | 452155 | 6323084 | 730821 | NP_013156.1 | NM_001181942.1
GenBank/EMBL/DDBJ: DAA09373.1 | M94955 | X94607 | Z73227
Amino Acid Sequence (or in FASTA format)
 
       1  MDEVDDILIN NQVVDDEEDD EEMLSGLEND SKQDLEGNDD GGEDEEDDDD
      51  DDEDDDDDED EREDDDEQED DDGEDDAARM DKTATPTNEH QHDEQKAAAA
     101  GAGGAGDSGD AVTKIGSEDV KLSDVDGGVG SREASSSTHE ASANGEVYEY
     151  YKHMLNAAQI ADSYNIYPTA AIPIQTHVNA LAVSRGLKYL FLGGSDGYIR
     201  KYDLLNTLEG KLSLTILQKH SLAESIQNAG ILQSYWENEI PQKKSEMKLS
     251  ANKTDYEPKV SPVHSLEVQS ECLFILSGLQ NGGITMQGVR YMEGSIAHYF
     301  KGRNGHTQIV NILRLNGQED RFLSGSWDKR LLEWDLQTGD IVNEFKKSRS
     351  ELSSLEMRPL YSSVDVSGNV NSGKENENAD DDMDSLFGDE DEDEKQDAGN
     401  EPVETGDGSN GEENKEQISE ESLNIVYDES VFMTSGLNGS VHIWDRRMTQ
     451  SPALSLERGA GVPPWCLSAC WGVDGDHVYA GRRNACVEQF DLKMPSKPIH
     501  NLKLPSISGP VSCVKAMPNN KHLLCASRDN IRLYNVEIAV DASNSTTKSS
     551  KVPFLIVPGH HGGIISNLYL DPTSRFIIST SGNRGWQGNS TDTTLIYDID
     601  LE*

external links for Spt8p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Spt8p
1) Sterner DE, et al.  (2002) SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. Proc Natl Acad Sci U S A 99(18):11622-7
2) Bhaumik SR and Green MR  (2002) Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo. Mol Cell Biol 22(21):7365-71
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41