STU2/YLR045C Protein Information Help

Standard Name Stu2p
Systematic Name Ylr045cp
ORF Classification Verified
Description Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p (1, 2, 3, 4)
Name Description Suppressor of tub2
Experimental Data
Molecules/cell 1660 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 888
Molecular Weight (Da) 100,917
Isoelectric Point (pI) 9.1

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Stu2p (InterPro)
Physical Interactions There are 63 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000136158 | P46675
MIPS: YLR045C
NCBI: 1015413 | 1174471 | 1181266 | 1360377 | 158430244 | 400977475 | 6323074 | NP_013146.1 | NM_001181932.1
GenBank/EMBL/DDBJ: AAA79057.1 | CAA64292.1 | CAA97574.1 | DAA09363.1 | U35247 | X94607 | Z73217
Amino Acid Sequence (or in FASTA format)
       1  MSGEEEVDYT TLPLEERLTY KLWKARLEAY KELNQLFRNS VGDISRDDNI
      51  QIYWRDPTLF AQYITDSNVV AQEQAIVALN SLIDAFASSS LKNAHNITLI
     101  STWTPLLVEK GLTSSRATTK TQSMSCILSL CGLDTSITQS VELVIPFFEK
     151  KLPKLIAAAA NCVYELMAAF GLTNVNVQTF LPELLKHVPQ LAGHGDRNVR
     201  SQTMNLIVEI YKVTGNNSDL LEEILFKKLK PIQVKDLHKL FAKVGDEPSS
     251  SKMLFEWEKR ELEKKRSQEE EARKRKSILS NDEGEYQIDK DGDTLMGMET
     301  DMPPSKQQSG VQIDTFSMLP EETILDKLPK DFQERITSSK WKDRVEALEE
     351  FWDSVLSQTK KLKSTSQNYS NLLGIYGHII QKDANIQAVA LAAQSVELIC
     401  DKLKTPGFSK DYVSLVFTPL LDRTKEKKPS VIEAIRKALL TICKYYDPLA
     451  SSGRNEDMLK DILEHMKHKT PQIRMECTQL FNASMKEEKD GYSTLQRYLK
     501  DEVVPIVIQI VNDTQPAIRT IGFESFAILI KIFGMNTFVK TLEHLDNLKR
     551  KKIEETVKTL PNFSIASGST HSTIETNKQT GPMENKFLLK KSSVLPSKRV
     601  ASSPLRNDNK SKVNPIGSVA SASKPSMVAA NNKSRVLLTS KSLATPKNVV
     651  ANSTDKNEKL IEEYKYRLQK LQNDEMIWTK ERQSLLEKMN NTENYKIEMI
     701  KENEMLREQL KEAQSKLNEK NIQLRSKEID VNKLSDRVLS LENELRNMEI
     751  ELDRNKKRND TNLQSMGTIS SYSIPSSTVS SNYGVKSLSS ALPFKEEEDV
     801  RRKEDVNYER RSSESIGDLP HRVNSLNIRP YRKNGTGVSS VSDDLDIDFN
     851  DSFASEESYK RAAAVTSTLK ARIEKMKAKS RREGTTRT*            

external links for Stu2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Stu2p
1) Chen XP, et al.  (1998) The yeast spindle pole body component Spc72p interacts with Stu2p and is required for proper microtubule assembly. J Cell Biol 141(5):1169-79
2) Wang PJ and Huffaker TC  (1997) Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body. J Cell Biol 139(5):1271-80
3) Severin F, et al.  (2001) Stu2 promotes mitotic spindle elongation in anaphase. J Cell Biol 153(2):435-42
4) Kosco KA, et al.  (2001) Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol Biol Cell 12(9):2870-80
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41