TRX1/YLR043C Protein Information 
| Standard Name | Trx1p |
|---|---|
| Systematic Name | Ylr043cp |
| Alias | Lma1p 1 |
| ORF Classification | Verified |
| Description | Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication (1, 10, 2, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | ThioRedoXin |
| Experimental Data | |
|---|---|
| Molecules/cell | 8580 11 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Trx1p (InterPro) |
| Physical Interactions | There are 26 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000004F943 | P22217 MIPS: YLR043C NCBI: 135747 | 1360373 | 152149105 | 173028 | 173048 | 261824811 | 261824812 | 261824813 | 45270296 | 6323072 | NP_013144.1 GenBank/EMBL/DDBJ: DAA09361.1 | AY558203 | M59169 | M62647 | Z73215 |
external links for Trx1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| Candida (CGD) | BioPIXIE | MIPS | YeastGFP |
| Candida (CandidaDB) | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| YGOB | Complexome | YeastRC Structure Prediction (Seattle) | |
| YOGY | GeneMANIA |
References cited on this page View Complete Literature Guide for Trx1p
| 1) | Xu Z and Wickner W (1996) Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae. J Cell Biol 132(5):787-94 |
| 2) | Pedrajas JR, et al. (1999) Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. J Biol Chem 274(10):6366-73 |
| 3) | Xu Z, et al. (1997) A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J Cell Biol 136(2):299-306 |
| 4) | Barlowe C (1997) Coupled ER to Golgi transport reconstituted with purified cytosolic proteins. J Cell Biol 139(5):1097-108 |
| 5) | Spang A and Schekman R (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99 |
| 6) | Garrido EO and Grant CM (2002) Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides. Mol Microbiol 43(4):993-1003 |
| 7) | Trotter EW and Grant CM (2002) Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae. Mol Microbiol 46(3):869-78 |
| 8) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 9) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 10) | Durigon R, et al. (2012) Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins. EMBO Rep 13(10):916-22 |
| 11) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
