PPR1/YLR014C Protein Information Help

Standard Name Ppr1p
Systematic Name Ylr014cp
ORF Classification Verified
Description Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p (1, 2, 3, 4)
Name Description Pyrimidine Pathway Regulation
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 904
Molecular Weight (Da) 102,723
Isoelectric Point (pI) 7.31

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ppr1p (InterPro)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001320FB | P07272
MIPS: YLR014C
NCBI: 130784 | 1360312 | 4215 | 6323042 | 975228 | 999798 | 999799 | NP_013114.1
GenBank/EMBL/DDBJ: DAA09332.1 | X01739 | X90564 | Z73186
Amino Acid Sequence (or in FASTA format)
 
       1  MKQKKFNSKK SNRTDLSKRG DSPNIGISKS RTACKRCRLK KIKCDQEFPS
      51  CKRCAKLEVP CVSLDPATGK DVPRSYVFFL EDRLAVMMRV LKEYGVDPTK
     101  IRGNIPATSD DEPFDLKKYS SVSSLGEEGI LPHNGLLADY LVQKGNSMAS
     151  SAITSKSMAS PQTINVQRKE FLVNSKKQDG SALLPETGSP MTSDARAEEL
     201  RRCNKEISAL GTMRESSFNS FLGDSSGISF AKLVFTATNF RQDSGDDVLD
     251  EDIKQREQKY NGYAEAENNP HFDPLELPPR HAAEVMISRF FVDTNSQLPL
     301  LHRELFLKKY FEPIYGPWNP NIALASDQTG INSAFEIPIT SAFSAHTEPK
     351  RENVTEKIDV CSSVDVPWYD TWETSQKVNM RPIVELPTKF HIPYFFLNII
     401  FAIGHATQVL KSDITTVATY KRRATKYIAS LFSSSDRLEA LAGTLLMVIY
     451  SIMRPNVPGV WYTMGSVLRL TVDLGLHSEK INKNYDAFTR EIRRRLFWCV
     501  YSLDRQICSY FGRPFGIPEE SITTRYPSLL DDSFITLTNR EIDDYSDLPS
     551  PNPSSKVIAL AMYKIRRIQA SIVRILYAPG AELPRRFMDL ESWRIETYNE
     601  LERWFQVDVP KNFEMMNCKF NSIWFDLNYH YSKSILYGLS PKFPTLNDTA
     651  FKIVLDSTKG TIDVFYNLCV NKKIGYTWVA VHNMFMTGMT YLYVNFYSKN
     701  NINDCQEKVS EYTEKVLIVL KNLIGFCESA KTCYTSYKIL SSVVIKLKFM
     751  QINDAKGIFS DSNPLTSQAN RMSSYDKKTN VLGFDDGTFD NKVFNRTNFE
     801  EKAPFDIPLD EFFTELEKHS NVSQFNTLDV SEGNQVINES ASTNTSSALN
     851  CQSYTNNQDI MDILFQVTSG SVWDEFFVRS GNGNEGESSY DISKGKNSES
     901  GGIF*

external links for Ppr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ppr1p
1) Todd RB and Andrianopoulos A  (1997) Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol 21(3):388-405
2) Flynn PJ and Reece RJ  (1999) Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathway. Mol Cell Biol 19(1):882-8
3) Liljelund P, et al.  (1984) Yeast regulatory gene PPR1. II. Chromosomal localization, meiotic map, suppressibility, dominance/recessivity and dosage effect. J Mol Biol 180(2):251-65
4) Patzold AJ and Lehming N  (2001) Why Ppr1p is a weak activator of transcription. FEBS Lett 494(1-2):64-8