YBT1/YLL048C Protein Information Help

Standard Name Ybt1p
Systematic Name Yll048cp
Alias Bat1p 1
ORF Classification Verified
Description Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication (1, 2, 3)
Name Description Yeast Bile Transporter
Experimental Data
Molecules/cell 3000 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,661
Molecular Weight (Da) 189,160
Isoelectric Point (pI) 8.13

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ybt1p (InterPro)
Transmembrane Domains There are 14 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 20 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013A3D8 | P32386
MIPS: YLL048C
NCBI: 1360247 | 3915963 | 532298 | 6322980 | NP_013052.1 | NM_001181868.1
GenBank/EMBL/DDBJ: DAA09276.1 | M88608 | Z73153
External Classifications TC: 3.A.1.208 [The Conjugate Transporter-2 (CT2) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MHHVLNSTRP DHRFWFYDDV TQYGRTKYLN YYTPLVLLIF TVLFITYNIW
      51  KHYYYYDVLH LKQKNPIDEL LYSSTDEDEQ SPLINNNTIT TNYVDNNCTK
     101  DALKNRHFSL EKLKSVKVNG EPHGTPEIVR RGFIEKSRII LEFFLVLSQV
     151  IIHSFILLHY VNKNPEFTQQ GTITGLVEWC ALFIIVSLRL ANVNQNFKFI
     201  NKYPGNLWSV SFINYLALFI SMILPFRSIF IHHINSPISR KYYISQISIN
     251  LALFLLLFFA RIRNNFAIIY KTDSWITPSP EPVTSIAGFI CWAWLDSFVW
     301  KAHKVSIKVK DIWGLMMQDY SFFVVKKFRY FVDHKVKRKR IFSLNLFFFF
     351  SNYLVLQCFW AFLGSVLSFI PTVLLKRILE YVEDQSSAPS NLAWFYVTVM
     401  FVGRILVAIC QAQALFFGRR VCIRMKSIII SEIYTKALRR KISTNKTKPS
     451  NEDPQEINDQ KSINGDEEST SSANLGAIIN LMAIDAFKVS EICGYLHSFL
     501  EAFVMTVVAL ALLYRLLGFA AIVGVLIIVA MLPLNYKLAK YIGDLQKKNL
     551  AVTDNRIQKL NEAFQAIRII KYFSWEENFE KDINTIRENE LSLLLMRSIV
     601  WSISSFLWFV TPTIVTAASF AYYIYVQGEV LTTPVAFTAL SLFTLLRDPL
     651  DRLSDMLSFV VQSKVSLDRV QDFLNENDTK KYDQLTIDPN GNRFAFENST
     701  ISWDKDNQDF KLKDLNIEFK TGKLNVVIGP TGSGKTSLLM ALLGEMYLLN
     751  GKVVVPALEP RQELIVDANG TTNSIAYCSQ AAWLLNDTVK NNILFNSPFN
     801  EARYKAVVEA CGLKRDFEIL KAGDLTEIGE KGITLSGGQK QRVSLARALY
     851  SNARHVLLDD CLSAVDSHTA SWIYDNCITG PLMEDRTCIL VSHNIALTLR
     901  NAELVVLLED GRVKDQGDPI DMLQKGLFGE DELVKSSILS RANSSANLAA
     951  KSSTSLSNLP AVKEQQVSVN NNSSHFEAKK LQKSLRTEAE RTEDGKLIKE
    1001  ETKEEGVVGL DVYKWYLKIF GGWKIVSFLA SLFLIAQLLY IGQSWWVRAW
    1051  ASHNVIAKII PRAQRAIAFI SKKASHLIDW RGSSQISMAS AENQPSSGHS
    1101  TMYYLVLYLI IGFAQALLGA GKTILNFVAG INASRKIFNM ILNKVLHSKI
    1151  RFFDATPTGR IMNRFSKDIE AIDQELTPYI QGAFYSLIEC LSTVILITFI
    1201  TPQFLSVAIV VSILYYFVGY FYMAGSRELK RFESISRSPI YQHFSETLVG
    1251  VTTIRAFGDE GRFMQENLHK IDENNKPFFY LWVANRWLAF RIDMIGSLVI
    1301  FGAGLFILFN INNLDSGMAG ISLTYAISFT EGALWLVRLY SEVEMNMNSV
    1351  ERVKEYMEIE QEPYNEHKEI PPPQWPQDGK IEVNDLSLRY APNLPRVIKN
    1401  VSFSVDAQSK IGIVGRTGAG KSTIITALFR FLEPETGHIK IDNIDISGVD
    1451  LQRLRRSITI IPQDPTLFSG TIKTNLDPYD EFSDRQIFEA LKRVNLISEE
    1501  QLQQGATRET SNEASSTNSE NVNKFLDLSS EISEGGSNLS QGQRQLMCLA
    1551  RSLLRSPKII LLDEATASID YSSDAKIQET IRKEFQGSTI LTIAHRLRSV
    1601  IDYDKILVMD AGEVKEYDHP YSLLLNKQSA FYSMCEHSGE LDILIELAKK
    1651  AFVEKLNSKK D*

external links for Ybt1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Ybt1p
1) Ortiz DF, et al.  (1997) A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. J Biol Chem 272(24):15358-65
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Sasser TL, et al.  (2012) The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation. Biochem J 448(3):365-72
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41