ATG10/YLL042C Protein Information Help

Standard Name Atg10p 1
Systematic Name Yll042cp
Alias Apg10p 2
ORF Classification Verified
Description Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy (2, 3, 4)
Name Description AuTophaGy related 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 167
Molecular Weight (Da) 19,759
Isoelectric Point (pI) 4.66

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Atg10p (InterPro)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006BB0B | Q07879
MIPS: YLL042C
NCBI: 1360237 | 407943844 | 407943845 | 414145776 | 414145777 | 45270270 | 61211722 | 6322986 | NP_013058.1
GenBank/EMBL/DDBJ: DAA09280.1 | AY558190 | Z73147
External Classifications EC: 6.3.2.- [Acid-Amino-Acid Ligases (Peptide Synthases)]
Amino Acid Sequence (or in FASTA format)
 
       1  MIPYQEWHSQ LQSLYDSQIF HNWALCQDVH LNDEKDGLLL RLIPTRQLQK
      51  NTERIENKLL NHIELYLTYS KVYNEPLLLL RIWEEKSIDG IPMTKLMLPT
     101  DIESLLDVQG KFQLGLDTII NLEGSVWYSF HPCDTSCIVG DQAEFMSTYL
     151  RRWVSIFIFS WLGYEDS*

external links for Atg10p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Atg10p
1) Klionsky DJ, et al.  (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2) Tsukada M and Ohsumi Y  (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
3) Shintani T, et al.  (1999) Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J 18(19):5234-41
4) Meijer WH, et al.  (2007) ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3(2):106-16