BPT1/YLL015W Protein Information

Standard Name	Bpt1p 1
Systematic Name	Yll015wp
ORF Classification	Verified
Description	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p (1, 2, 3)
Name Description	Bile Pigment Transporter 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,559
Molecular Weight (Da)	176,872
Isoelectric Point (pI)	7.63

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bpt1p (InterPro)
Transmembrane Domains	There are 14 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000126A9C \| P14772 MIPS: YLL015W NCBI: 1297015 \| 1360185 \| 1495208 \| 2506123 \| 457495 \| 6323014 \| NP_013086.1 GenBank/EMBL/DDBJ: DAA09303.1 \| M26647 \| X91488 \| X97560 \| Z73120
External Classifications	TC: 3.A.1.208 [The Conjugate Transporter-2 (CT2) Family]

Amino Acid Sequence (or in FASTA format)
1 MSSLEVVDGC PYGYRPYPDS GTNALNPCFI SVISAWQAVF FLLIGSYQLW 51 KLYKNNKVPP RFKNFPTLPS KINSRHLTHL TNVCFQSTLI ICELALVSQS 101 SDRVYPFILK KALYLNLLFN LGISLPTQYL AYFKSTFSMG NQLFYYMFQI 151 LLQLFLILQR YYHGSSNERL TVISGQTAMI LEVLLLFNSV AIFIYDLCIF 201 EPINELSEYY KKNGWYPPVH VLSYITFIWM NKLIVETYRN KKIKDPNQLP 251 LPPVDLNIKS ISKEFKANWE LEKWLNRNSL WRAIWKSFGR TISVAMLYET 301 TSDLLSVVQP QFLRIFIDGL NPETSSKYPP LNGVFIALTL FVISVVSVFL 351 TNQFYIGIFE AGLGIRGSLA SLVYQKSLRL TLAERNEKST GDILNLMSVD 401 VLRIQRFFEN AQTIIGAPIQ IIVVLTSLYW LLGKAVIGGL VTMAIMMPIN 451 AFLSRKVKKL SKTQMKYKDM RIKTITELLN AIKSIKLYAW EEPMMARLNH 501 VRNDMELKNF RKIGIVSNLI YFAWNCVPLM VTCSTFGLFS LFSDSPLSPA 551 IVFPSLSLFN ILNSAIYSVP SMINTIIETS VSMERLKSFL LSDEIDDSFI 601 ERIDPSADER ALPAIEMNNI TFLWKSKEVL TSSQSGDNLR TDEESIIGSS 651 QIALKNIDHF EAKRGDLVCV VGRVGAGKST FLKAILGQLP CMSGSRDSIP 701 PKLIIRSSSV AYCSQESWIM NASVRENILF GHKFDQDYYD LTIKACQLLP 751 DLKILPDGDE TLVGEKGISL SGGQKARLSL ARAVYSRADI YLLDDILSAV 801 DAEVSKNIIE YVLIGKTALL KNKTIILTTN TVSILKHSQM IYALENGEIV 851 EQGNYEDVMN RKNNTSKLKK LLEEFDSPID NGNESDVQTE HRSESEVDEP 901 LQLKVTESET EDEVVTESEL ELIKANSRRA SLATLRPRPF VGAQLDSVKK 951 TAQKAEKTEV GRVKTKIYLA YIKACGVLGV VLFFLFMILT RVFDLAENFW 1001 LKYWSESNEK NGSNERVWMF VGVYSLIGVA SAAFNNLRSI MMLLYCSIRG 1051 SKKLHESMAK SVIRSPMTFF ETTPVGRIIN RFSSDMDAVD SNLQYIFSFF 1101 FKSILTYLVT VILVGYNMPW FLVFNMFLVV IYIYYQTFYI VLSRELKRLI 1151 SISYSPIMSL MSESLNGYSI IDAYDHFERF IYLNYEKIQY NVDFVFNFRS 1201 TNRWLSVRLQ TIGATIVLAT AILALATMNT KRQLSSGMVG LLMSYSLEVT 1251 GSLTWIVRTT VTIETNIVSV ERIVEYCELP PEAQSINPEK RPDENWPSKG 1301 GIEFKNYSTK YRENLDPVLN NINVKIEPCE KVGIVGRTGA GKSTLSLALF 1351 RILEPTEGKI IIDGIDISDI GLFDLRSHLA IIPQDAQAFE GTVKTNLDPF 1401 NRYSEDELKR AVEQAHLKPH LEKMLHSKPR GDDSNEEDGN VNDILDVKIN 1451 ENGSNLSVGQ RQLLCLARAL LNRSKILVLD EATASVDMET DKIIQDTIRR 1501 EFKDRTILTI AHRIDTVLDS DKIIVLDQGS VREFDSPSKL LSDKTSIFYS 1551 LCEKGGYLK*

Amino Acid Sequence (or in FASTA format)

       1  MSSLEVVDGC PYGYRPYPDS GTNALNPCFI SVISAWQAVF FLLIGSYQLW
      51  KLYKNNKVPP RFKNFPTLPS KINSRHLTHL TNVCFQSTLI ICELALVSQS
     101  SDRVYPFILK KALYLNLLFN LGISLPTQYL AYFKSTFSMG NQLFYYMFQI
     151  LLQLFLILQR YYHGSSNERL TVISGQTAMI LEVLLLFNSV AIFIYDLCIF
     201  EPINELSEYY KKNGWYPPVH VLSYITFIWM NKLIVETYRN KKIKDPNQLP
     251  LPPVDLNIKS ISKEFKANWE LEKWLNRNSL WRAIWKSFGR TISVAMLYET
     301  TSDLLSVVQP QFLRIFIDGL NPETSSKYPP LNGVFIALTL FVISVVSVFL
     351  TNQFYIGIFE AGLGIRGSLA SLVYQKSLRL TLAERNEKST GDILNLMSVD
     401  VLRIQRFFEN AQTIIGAPIQ IIVVLTSLYW LLGKAVIGGL VTMAIMMPIN
     451  AFLSRKVKKL SKTQMKYKDM RIKTITELLN AIKSIKLYAW EEPMMARLNH
     501  VRNDMELKNF RKIGIVSNLI YFAWNCVPLM VTCSTFGLFS LFSDSPLSPA
     551  IVFPSLSLFN ILNSAIYSVP SMINTIIETS VSMERLKSFL LSDEIDDSFI
     601  ERIDPSADER ALPAIEMNNI TFLWKSKEVL TSSQSGDNLR TDEESIIGSS
     651  QIALKNIDHF EAKRGDLVCV VGRVGAGKST FLKAILGQLP CMSGSRDSIP
     701  PKLIIRSSSV AYCSQESWIM NASVRENILF GHKFDQDYYD LTIKACQLLP
     751  DLKILPDGDE TLVGEKGISL SGGQKARLSL ARAVYSRADI YLLDDILSAV
     801  DAEVSKNIIE YVLIGKTALL KNKTIILTTN TVSILKHSQM IYALENGEIV
     851  EQGNYEDVMN RKNNTSKLKK LLEEFDSPID NGNESDVQTE HRSESEVDEP
     901  LQLKVTESET EDEVVTESEL ELIKANSRRA SLATLRPRPF VGAQLDSVKK
     951  TAQKAEKTEV GRVKTKIYLA YIKACGVLGV VLFFLFMILT RVFDLAENFW
    1001  LKYWSESNEK NGSNERVWMF VGVYSLIGVA SAAFNNLRSI MMLLYCSIRG
    1051  SKKLHESMAK SVIRSPMTFF ETTPVGRIIN RFSSDMDAVD SNLQYIFSFF
    1101  FKSILTYLVT VILVGYNMPW FLVFNMFLVV IYIYYQTFYI VLSRELKRLI
    1151  SISYSPIMSL MSESLNGYSI IDAYDHFERF IYLNYEKIQY NVDFVFNFRS
    1201  TNRWLSVRLQ TIGATIVLAT AILALATMNT KRQLSSGMVG LLMSYSLEVT
    1251  GSLTWIVRTT VTIETNIVSV ERIVEYCELP PEAQSINPEK RPDENWPSKG
    1301  GIEFKNYSTK YRENLDPVLN NINVKIEPCE KVGIVGRTGA GKSTLSLALF
    1351  RILEPTEGKI IIDGIDISDI GLFDLRSHLA IIPQDAQAFE GTVKTNLDPF
    1401  NRYSEDELKR AVEQAHLKPH LEKMLHSKPR GDDSNEEDGN VNDILDVKIN
    1451  ENGSNLSVGQ RQLLCLARAL LNRSKILVLD EATASVDMET DKIIQDTIRR
    1501  EFKDRTILTI AHRIDTVLDS DKIIVLDQGS VREFDSPSKL LSDKTSIFYS
    1551  LCEKGGYLK*

external links for Bpt1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Bpt1p

1)	Petrovic S, et al. (2000) The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16(6):561-71
2)	Bauer BE, et al. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim Biophys Acta 1461(2):217-36
3)	Klein M, et al. (2002) The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast. FEBS Lett 520(1-3):63-7