EMC6/YLL014W Protein Information Help

Standard Name Emc6p 1
Systematic Name Yll014wp
ORF Classification Verified
Description Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 (1, 2)
Name Description ER Membrane protein Complex 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 108
Molecular Weight (Da) 12,404
Isoelectric Point (pI) 4.98

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Emc6p (InterPro)
Transmembrane Domains There are 3 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 6 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006A972 | Q12431
MIPS: YLL014W
NCBI: 1297016 | 1360183 | 1495210 | 45269743 | 6323015 | 74676600 | NP_013087.1
GenBank/EMBL/DDBJ: DAA09304.1 | AY557926 | X91488 | X97560 | Z73119
Amino Acid Sequence (or in FASTA format)
 
       1  MSSNEEVFTQ INATANVVDN KKRLLFVQDS SALVLGLVAG FLQIESVHGF
      51  IWFLILYNLI NVIYIVWICQ LQPGKFYQSP LHDIFFESFF REITGFVMAW
     101  TFGYALIG*

external links for Emc6p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome

YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Emc6p
1) Jonikas MC, et al.  (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
2) Richard M, et al.  (2013) Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Proc Natl Acad Sci U S A 110(11):E1055-63