PSR1/YLL010C Protein Information Help

Standard Name Psr1p 1
Systematic Name Yll010cp
ORF Classification Verified
Description Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR1 has a paralog, PSR2, that arose from the whole genome duplication (1, 2, 3)
Name Description Plasma membrane Sodium Response 1
Experimental Data
Molecules/cell 5620 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 427
Molecular Weight (Da) 47,930
Isoelectric Point (pI) 4.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Psr1p (InterPro)
Physical Interactions There are 17 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000069CDA | Q07800
MIPS: YLL010C
NCBI: 1360175 | 1495214 | 55583861 | 6323019 | NP_013091.1 | NM_001181830.1
GenBank/EMBL/DDBJ: CAA62782.1 | CAA97454.1 | DAA09308.1 | X91488 | Z73115
External Classifications EC: 3.1.3.- [Phosphoric Monoester Hydrolases]
Amino Acid Sequence (or in FASTA format)
       1  MGFISSILCC SSETTQSNSN SAYRQQQSSS LNKNRSVKHS NTKSRTRGVH
      51  QTNSPPSKTN SAATFSSTER STGKSGISTN DNEKKKPSSP TAAVTATTTN
     101  NMTKVEKRIS KDDLYEEKYE VDEDEEIDDE DNRRSRGIVQ EKGDAVKDTS
     151  RQKKQQQQQQ QQSQPQPQPQ SQSQSQSQSQ SQQRGPTVQV SSDHLIQDMN
     201  LSRVSSSSQA SETSNDADDE DDEDEEYIDL TLLQQGQYHA PGYNTLLPPQ
     251  DESTKGKKCL ILDLDETLVH SSFKYLRSAD FVLSVEIDDQ VHNVYVIKRP
     301  GVEEFLERVG KLFEVVVFTA SVSRYGDPLL DILDTDKVIH HRLFREACYN
     351  YEGNYIKNLS QIGRPLSDII ILDNSPASYI FHPQHAIPIS SWFSDTHDNE
     401  LLDIIPLLED LSVKTSLDVG KILDVTI*                        

external links for Psr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Psr1p
1) Siniossoglou S, et al.  (2000) Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. J Biol Chem 275(25):19352-60
2) Kaida D, et al.  (2002) Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Genes Cells 7(6):543-52
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41