PSR1/YLL010C Protein Information

Standard Name	Psr1p 1
Systematic Name	Yll010cp
ORF Classification	Verified
Description	Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR1 has a paralog, PSR2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Plasma membrane Sodium Response 1

Experimental Data
Molecules/cell	5620 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	427
Molecular Weight (Da)	47,930
Isoelectric Point (pI)	4.86

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Psr1p (InterPro)
Physical Interactions	There are 15 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000069CDA \| Q07800 MIPS: YLL010C NCBI: 1360175 \| 1495214 \| 55583861 \| 6323019 \| NP_013091.1 GenBank/EMBL/DDBJ: DAA09308.1 \| X91488 \| Z73115
External Classifications	EC: 3.1.3.- [Phosphoric Monoester Hydrolases]

Amino Acid Sequence (or in FASTA format)
1 MGFISSILCC SSETTQSNSN SAYRQQQSSS LNKNRSVKHS NTKSRTRGVH 51 QTNSPPSKTN SAATFSSTER STGKSGISTN DNEKKKPSSP TAAVTATTTN 101 NMTKVEKRIS KDDLYEEKYE VDEDEEIDDE DNRRSRGIVQ EKGDAVKDTS 151 RQKKQQQQQQ QQSQPQPQPQ SQSQSQSQSQ SQQRGPTVQV SSDHLIQDMN 201 LSRVSSSSQA SETSNDADDE DDEDEEYIDL TLLQQGQYHA PGYNTLLPPQ 251 DESTKGKKCL ILDLDETLVH SSFKYLRSAD FVLSVEIDDQ VHNVYVIKRP 301 GVEEFLERVG KLFEVVVFTA SVSRYGDPLL DILDTDKVIH HRLFREACYN 351 YEGNYIKNLS QIGRPLSDII ILDNSPASYI FHPQHAIPIS SWFSDTHDNE 401 LLDIIPLLED LSVKTSLDVG KILDVTI*

Amino Acid Sequence (or in FASTA format)

       1  MGFISSILCC SSETTQSNSN SAYRQQQSSS LNKNRSVKHS NTKSRTRGVH
      51  QTNSPPSKTN SAATFSSTER STGKSGISTN DNEKKKPSSP TAAVTATTTN
     101  NMTKVEKRIS KDDLYEEKYE VDEDEEIDDE DNRRSRGIVQ EKGDAVKDTS
     151  RQKKQQQQQQ QQSQPQPQPQ SQSQSQSQSQ SQQRGPTVQV SSDHLIQDMN
     201  LSRVSSSSQA SETSNDADDE DDEDEEYIDL TLLQQGQYHA PGYNTLLPPQ
     251  DESTKGKKCL ILDLDETLVH SSFKYLRSAD FVLSVEIDDQ VHNVYVIKRP
     301  GVEEFLERVG KLFEVVVFTA SVSRYGDPLL DILDTDKVIH HRLFREACYN
     351  YEGNYIKNLS QIGRPLSDII ILDNSPASYI FHPQHAIPIS SWFSDTHDNE
     401  LLDIIPLLED LSVKTSLDVG KILDVTI*

external links for Psr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Psr1p

1)	Siniossoglou S, et al. (2000) Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. J Biol Chem 275(25):19352-60
2)	Kaida D, et al. (2002) Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Genes Cells 7(6):543-52
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41