DRS1/YLL008W Protein Information Help

Standard Name Drs1p
Systematic Name Yll008wp
ORF Classification Verified
Description Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles (1, 2, 3)
Name Description Deficiency of Ribosomal Subunits 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 752
Molecular Weight (Da) 84,842
Isoelectric Point (pI) 5.51

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Drs1p (InterPro)
Physical Interactions There are 114 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053114 | P32892
MIPS: YLL008W
NCBI: 1360171 | 1495215 | 1706521 | 171656 | 6323021 | NP_013093.1
GenBank/EMBL/DDBJ: DAA09310.1 | L00683 | X91488 | Z73113
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MVVGTKKYSN LDFVPTISDS EDDVPILDSS DDEKVEAKKT TKKRKGKNNK
      51  KKVSEGDNLD EDVHEDLDAG FKFDLDADDT TSNFQGWNFL AEGESNKDDA
     101  EAFVKKDVDL DKIIRRKGGL VKMAHIDSKQ EEETEKEKVE KENDSDDEEL
     151  AMDGFGMGAP MNNGDENQSE EEEEEEEKEE EEEEEEEQEE MTLEKGGKDD
     201  EIDEEDDSEE AKADFYAPET EGDEAKKQMY ENFNSLSLSR PVLKGLASLG
     251  YVKPSPIQSA TIPIALLGKD IIAGAVTGSG KTAAFMIPII ERLLYKPAKI
     301  ASTRVIVLLP TRELAIQVAD VGKQIARFVS GITFGLAVGG LNLRQQEQML
     351  KSRPDIVIAT PGRFIDHIRN SASFNVDSVE ILVMDEADRM LEEGFQDELN
     401  EIMGLLPSNR QNLLFSATMN SKIKSLVSLS LKKPVRIMID PPKKAATKLT
     451  QEFVRIRKRD HLKPALLFNL IRKLDPTGQK RIVVFVARKE TAHRLRIIMG
     501  LLGMSVGELH GSLTQEQRLD SVNKFKNLEV PVLICTDLAS RGLDIPKIEV
     551  VINYDMPKSY EIYLHRVGRT ARAGREGRSV TFVGESSQDR SIVRAAIKSV
     601  EENKSLTQGK ALGRNVDWVQ IEETNKLVES MNDTIEDILV EEKEEKEILR
     651  AEMQLRKGEN MLKHKKEIQA RPRRTWFQSE SDKKNSKVLG ALSRNKKVTN
     701  SKKRKREEAK ADGNGARSYR KTKTDRIADQ ERTFKKQKST NSNKKKGFKS
     751  RR*

external links for Drs1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Drs1p
1) Ripmaster TL, et al.  (1993) DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7901-12
2) Adams CC, et al.  (2002) Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits. RNA 8(2):150-65
3) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4) Ripmaster TL, et al.  (1992) A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Proc Natl Acad Sci U S A 89(23):11131-5