DNM1/YLL001W Protein Information Help

Standard Name Dnm1p
Systematic Name Yll001wp
ORF Classification Verified
Description Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance (1, 2, 3, 4, 5)
Name Description DyNaMin-related 6
Experimental Data
Molecules/cell 9620 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 757
Molecular Weight (Da) 84,971
Isoelectric Point (pI) 5.25

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Dnm1p (InterPro)
Physical Interactions There are 57 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000129697 | P54861
MIPS: YLL001W
NCBI: 1360157 | 1495224 | 1706485 | 6323028 | 710602 | NP_013100.1
GenBank/EMBL/DDBJ: DAA09318.1 | L40588 | X91488 | Z73106
External Classifications EC: 3.6.5.5 [Dynamin GTPase]
Amino Acid Sequence (or in FASTA format)
 
       1  MASLEDLIPT VNKLQDVMYD SGIDTLDLPI LAVVGSQSSG KSSILETLVG
      51  RDFLPRGTGI VTRRPLVLQL NNISPNSPLI EEDDNSVNPH DEVTKISGFE
     101  AGTKPLEYRG KERNHADEWG EFLHIPGKRF YDFDDIKREI ENETARIAGK
     151  DKGISKIPIN LKVFSPHVLN LTLVDLPGIT KVPIGEQPPD IEKQIKNLIL
     201  DYIATPNCLI LAVSPANVDL VNSESLKLAR EVDPQGKRTI GVITKLDLMD
     251  SGTNALDILS GKMYPLKLGF VGVVNRSQQD IQLNKTVEES LDKEEDYFRK
     301  HPVYRTISTK CGTRYLAKLL NQTLLSHIRD KLPDIKTKLN TLISQTEQEL
     351  ARYGGVGATT NESRASLVLQ LMNKFSTNFI SSIDGTSSDI NTKELCGGAR
     401  IYYIYNNVFG NSLKSIDPTS NLSVLDVRTA IRNSTGPRPT LFVPELAFDL
     451  LVKPQIKLLL EPSQRCVELV YEELMKICHK CGSAELARYP KLKSMLIEVI
     501  SELLRERLQP TRSYVESLID IHRAYINTNH PNFLSATEAM DDIMKTRRKR
     551  NQELLKSKLS QQENGQTNGI NGTSSISSNI DQDSAKNSDY DDDGIDAESK
     601  QTKDKFLNYF FGKDKKGQPV FDASDKKRSI AGDGNIEDFR NLQISDFSLG
     651  DIDDLENAEP PLTEREELEC ELIKRLIVSY FDIIREMIED QVPKAVMCLL
     701  VNYCKDSVQN RLVTKLYKET LFEELLVEDQ TLAQDRELCV KSLGVYKKAA
     751  TLISNIL*

external links for Dnm1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Dnm1p
1) Otsuga D, et al.  (1998) The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J Cell Biol 143(2):333-49
2) Gammie AE, et al.  (1995) DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast. J Cell Biol 130(3):553-66
3) Bleazard W, et al.  (1999) The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat Cell Biol 1(5):298-304
4) Mozdy AD, et al.  (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
5) Kuravi K, et al.  (2006) Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci 119(Pt 19):3994-4001
6) Gammie AE and Rose MD  (1995) Identification and characterization of CEN12 in the budding yeast Saccharomyces cerevisiae. Curr Genet 28(6):512-6
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41