HMS2/YJR147W Protein Information

Standard Name	Hms2p 1
Systematic Name	Yjr147wp
ORF Classification	Verified
Description	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication (1, 2)
Name Description	High-copy Mep Suppressor 1

Experimental Data
Molecules/cell	2050 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	358
Molecular Weight (Da)	41,192
Isoelectric Point (pI)	9.71

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hms2p (InterPro)
Physical Interactions	There are 35 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B508 \| P47175 MIPS: YJR147W NCBI: 1015895 \| 1352940 \| 6322607 \| NP_012681.1 \| NM_001181805.1 GenBank/EMBL/DDBJ: DAA08931.1 \| Z49646

Amino Acid Sequence (or in FASTA format)
1 MDATSRMEQP DVFVSKLYHL LQGNAYSNII QWSTDGSKLV IWNPDQFTKV 51 ILERFFGIHT FAAFVKQLSK YNFQKAGRPD CVEFSNIHFQ KDNINSLSLV 101 KAHQSAATPN VAAVNNMNKQ CTFHWDPFKV NSILSKAIGK PSFEKLVKNV 151 DRLQGNLDEL KSTNADSLRI IREINASLQT ISYHQFHAYQ TANFLQENFE 201 AIKKVVCPDS CLQHQQRQPK RPKRYSLLLL IPNASELSET PLMRFAGVFE 251 FMNCSLDTAT QWHPQLHPEA YDLLFVTVSP NMQQEHLIYF KRLRNLLPSF 301 PVIAIINRPV SPQDTSIAPS NYSRYYFHHF LQLGFSDILV SPFTPTQLIT 351 LLSKHLRT*

Amino Acid Sequence (or in FASTA format)

       1  MDATSRMEQP DVFVSKLYHL LQGNAYSNII QWSTDGSKLV IWNPDQFTKV
      51  ILERFFGIHT FAAFVKQLSK YNFQKAGRPD CVEFSNIHFQ KDNINSLSLV
     101  KAHQSAATPN VAAVNNMNKQ CTFHWDPFKV NSILSKAIGK PSFEKLVKNV
     151  DRLQGNLDEL KSTNADSLRI IREINASLQT ISYHQFHAYQ TANFLQENFE
     201  AIKKVVCPDS CLQHQQRQPK RPKRYSLLLL IPNASELSET PLMRFAGVFE
     251  FMNCSLDTAT QWHPQLHPEA YDLLFVTVSP NMQQEHLIYF KRLRNLLPSF
     301  PVIAIINRPV SPQDTSIAPS NYSRYYFHHF LQLGFSDILV SPFTPTQLIT
     351  LLSKHLRT*

external links for Hms2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Hms2p

1)	Lorenz MC and Heitman J (1998) Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Genetics 150(4):1443-57
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41