NMD5/YJR132W Protein Information

Standard Name	Nmd5p
Systematic Name	Yjr132wp
Alias	Kap119p 1
ORF Classification	Verified
Description	Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog (1, 2, 3)

Experimental Data
Molecules/cell	13500 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,048
Molecular Weight (Da)	119,967
Isoelectric Point (pI)	4.32

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nmd5p (InterPro)
Physical Interactions	There are 38 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD56 \| P46970 MIPS: YJR132W NCBI: 1015866 \| 1171739 \| 330443627 \| 347595679 \| 950222 \| NP_012666.2 GenBank/EMBL/DDBJ: DAA08916.2 \| U31375 \| Z49632

Amino Acid Sequence (or in FASTA format)
1 MDITELLQCF ACTLDHNAAV RTNAETHLKN ASKVPGFLGA CLDIIAADEV 51 PENIKLSASL YFKNKITYGW SAGARQGSNE LLDSHVDPDE KPVVKDMLIK 101 TMVSVSKTSP RCIRVLKSAL TVIISEDYPS KKWGNLLPNS LELLANEDIT 151 VTYVGLLCLA EIFRTYRWKN NDERQDLEEL ILNYFPALLN YGANVLFQDG 201 KYMNNEQIGE LVKLIIKIYK FVSYHDLPFT LQRSESFTPW ACFFVSIIQQ 251 PLPQEVLAIS DIEVRSKNPW VKCKKWALAN LYRLFQRYAS TSLTRKFQYD 301 EFKQMYCEEF LTQFLQVVFD QIEKWGTGQL WLSDECLYYI LNFVEQCVVQ 351 KTTWKLVGPH YNVILQHVIF PLLKPTAETL EAFDNDPQEY INRNMDFWDV 401 GYSPDLAALA LLTTCVTKRG KTTLQPTLEF MVSTLQSAVG DYNNIMLDNA 451 LQIESCLRIF SSIIDRLITK DSPFASEMEK FILTYVLPFF KSQYGFLQSR 501 VCDICSKLGS MDFKDPVITS TIYEGVMNCL NNSSNSLPVE LTAALALQTF 551 ISDDQFNMKL SEHVVPTMQK LLSLSNDFES DVISGVMQDF VEQFAEQLQP 601 FGVELMNTLV QQFLKLAIDL HETSNLDPDS FTNVDSIPDE SDKQMAALGI 651 LSTTISILLS FENSPEILKN LEQSFYPAAE FILKNDIEDF YRECCEFVEN 701 STFLLRDITP ISWKILELIG ECNRKPDSMV SYYLSDFMLA LNNILIYGRN 751 ELKKNEFYTK IIFEIYQKAV TAEDNSLDDL RVVFDLSQEL VLALDDSLPQ 801 QYRERLLADV VGSILTQKNE LKTNVVFSVT AFNVVISNMI TEPLITLQYL 851 KQQGCLEIFF QTWITDYIPN YKRCYDIKLS VLALLKIILK LESNDYSVLN 901 LENLVPQLGS IVTQLASRLP TALRQLANQR KEFSSSGFEE DTKWDENFLD 951 VGDDDENDDE GDLTEKYLEL IKNRADSLDF VDGYDAKETF DDLEEDPLTG 1001 SILDTVDVYK VFKESIANLQ HVDSNRYQGI LRHLTPADQE LFMGIMNA*

Amino Acid Sequence (or in FASTA format)

       1  MDITELLQCF ACTLDHNAAV RTNAETHLKN ASKVPGFLGA CLDIIAADEV
      51  PENIKLSASL YFKNKITYGW SAGARQGSNE LLDSHVDPDE KPVVKDMLIK
     101  TMVSVSKTSP RCIRVLKSAL TVIISEDYPS KKWGNLLPNS LELLANEDIT
     151  VTYVGLLCLA EIFRTYRWKN NDERQDLEEL ILNYFPALLN YGANVLFQDG
     201  KYMNNEQIGE LVKLIIKIYK FVSYHDLPFT LQRSESFTPW ACFFVSIIQQ
     251  PLPQEVLAIS DIEVRSKNPW VKCKKWALAN LYRLFQRYAS TSLTRKFQYD
     301  EFKQMYCEEF LTQFLQVVFD QIEKWGTGQL WLSDECLYYI LNFVEQCVVQ
     351  KTTWKLVGPH YNVILQHVIF PLLKPTAETL EAFDNDPQEY INRNMDFWDV
     401  GYSPDLAALA LLTTCVTKRG KTTLQPTLEF MVSTLQSAVG DYNNIMLDNA
     451  LQIESCLRIF SSIIDRLITK DSPFASEMEK FILTYVLPFF KSQYGFLQSR
     501  VCDICSKLGS MDFKDPVITS TIYEGVMNCL NNSSNSLPVE LTAALALQTF
     551  ISDDQFNMKL SEHVVPTMQK LLSLSNDFES DVISGVMQDF VEQFAEQLQP
     601  FGVELMNTLV QQFLKLAIDL HETSNLDPDS FTNVDSIPDE SDKQMAALGI
     651  LSTTISILLS FENSPEILKN LEQSFYPAAE FILKNDIEDF YRECCEFVEN
     701  STFLLRDITP ISWKILELIG ECNRKPDSMV SYYLSDFMLA LNNILIYGRN
     751  ELKKNEFYTK IIFEIYQKAV TAEDNSLDDL RVVFDLSQEL VLALDDSLPQ
     801  QYRERLLADV VGSILTQKNE LKTNVVFSVT AFNVVISNMI TEPLITLQYL
     851  KQQGCLEIFF QTWITDYIPN YKRCYDIKLS VLALLKIILK LESNDYSVLN
     901  LENLVPQLGS IVTQLASRLP TALRQLANQR KEFSSSGFEE DTKWDENFLD
     951  VGDDDENDDE GDLTEKYLEL IKNRADSLDF VDGYDAKETF DDLEEDPLTG
    1001  SILDTVDVYK VFKESIANLQ HVDSNRYQGI LRHLTPADQE LFMGIMNA*

external links for Nmd5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Nmd5p

1)	Albertini M, et al. (1998) A novel nuclear import pathway for the transcription factor TFIIS. J Cell Biol 143(6):1447-55
2)	Ferrigno P, et al. (1998) Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J 17(19):5606-14
3)	Polizotto RS and Cyert MS (2001) Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p. J Cell Biol 154(5):951-60
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41