RSF2/YJR127C Protein Information Help

Standard Name Rsf2p 1
Systematic Name Yjr127cp
Alias Zms1p 2
ORF Classification Verified
Description Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress (1, 2, 3, 4, 5, 6)
Name Description ReSpiration Factor 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,380
Molecular Weight (Da) 155,061
Isoelectric Point (pI) 7.93

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rsf2p (InterPro)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 5 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013C3F6 | P46974
MIPS: YJR127C
NCBI: 1015857 | 1177049 | 398365503 | 432498 | NP_012661.3
GenBank/EMBL/DDBJ: DAA08912.1 | L26506 | Z49627
Amino Acid Sequence (or in FASTA format)
 
       1  MEPFAFGRGA PALCILTAAA RINLDNFVPC CWALFRLSFF FPLDPAYIRN
      51  ENKETRTSWI SIEFFFFVKH CLSQHTFFSK TLAPKRNFRA KKLKDIGDTR
     101  IDRADKDFLL VPEPSMFVNG NQSNFAKPAG QGILPIPKKS RIIKTDKPRP
     151  FLCPTCTRGF VRQEHLKRHQ HSHTREKPYL CIFCGRCFAR RDLVLRHQQK
     201  LHAALVGTGD PRRMTPAPNS TSSFASKRRH SVAADDPTDL HIIKIAGNKE
     251  TILPTPKNLA GKTSEELKEA VVALAKSNNV ELPVSAPVMN DKREKTPPSK
     301  AGSLGFREFK FSTKGVPVHS ASSDAVIDRA NTPSSMHKTK RHASFSASSA
     351  MTYMSSSNSP HHSITNFELV EDAPHQVGFS TPQMTAKQLM ESVSELDLPP
     401  LTLDEPPQAI KFNLNLFNND PSGQQQQQQQ QQQNSTSSTI VNSNNGSTVA
     451  TPGVYLLSSG PSLTDLLTMN SAHAGAGGYM SSHHSPFDLG CFSHDKPTVS
     501  EFNLPSSFPN TIPSNSTTAS NSYSNLANQT YRQMSNEQPL MSLSPKNPPT
     551  TVSDSSSTIN FNPGTNNLLE PSMEPNDKDS NIDPAAIDDK WLSEFINNSD
     601  PKSTFKINFN HFNDIGFIYS PPSSRSSIPN KSPPNHSATS LNHEKASLSP
     651  RLNLSLNGST DLPSTPQNQL KEPSYSDPIS HSSHKRRRDS VMMDYDLSNF
     701  FSSRQLDISK VLNGTEQNNS HVNDDVLTLS FPGETDSNAT QKQLPVLTPS
     751  DLLSPFSVPS VSQVLFTNEL RSMMLADNNI DSGAFPTTSQ LNDYVTYYKE
     801  EFHPFFSFIH LPSIIPNMDS YPLLLSISMV GALYGFHSTH AKVLANAAST
     851  QIRKSLKVSE KNPETTELWV IQTLVLLTFY CIFNKNTAVI KGMHGQLTTI
     901  IRLLKASRLN LPLESLCQPP IESDHIMEYE NSPHMFSKIR EQYNAPNQMN
     951  KNYQYFVLAQ SRIRTCHAVL LISNLFSSLV GADCCFHSVD LKCGVPCYKE
    1001  ELYQCRNSDE WSDLLCQYKI TLDSKFSLIE LSNGNEAYEN CLRFLSTGDS
    1051  FFYGNARVSL STCLSLLISI HEKILIERNN ARISNNNTNS NNIELDDIEW
    1101  KMTSRQRIDT MLKYWENLYL KNGGILTPTE NSMSTINANP AMRLIIPVYL
    1151  FAKMRRCLDL AHVIEKIWLK DWSNMNKALE EVCYDMGSLR EATEYALNMV
    1201  DAWTSFFTYI KQGKRRIFNT PVFATTCMFT AVLVISEYMK CVEDWARGYN
    1251  ANNPNSALLD FSDRVLWLKA ERILRRLQMN LIPKECDVLK SYTDFLRWQD
    1301  KDALDLSALN EEQAQRAMDP NTDINETIQL IVAASLSSKC LYLGVQILGD
    1351  APIWPIILSF AHGLQSRAIY SVTKKRNTRI *

external links for Rsf2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
YGOB CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rsf2p
1) Lu L, et al.  (2005) The YJR127C/ZMS1 gene product is involved in glycerol-based respiratory growth of the yeast Saccharomyces cerevisiae. Curr Genet 48(4):235-46
2) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
3) Grabowska D and Chelstowska A  (2003) The ALD6 gene product is indispensable for providing NADPH in yeast cells lacking glucose-6-phosphate dehydrogenase activity. J Biol Chem 278(16):13984-8
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76