ATP2/YJR121W Protein Information

Standard Name	Atp2p
Systematic Name	Yjr121wp
ORF Classification	Verified
Description	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated (1, 2)
Name Description	ATP synthase

Experimental Data
Molecules/cell	164000 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	511
Molecular Weight (Da)	54,793
Isoelectric Point (pI)	5.5

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atp2p (InterPro)
Physical Interactions	There are 92 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EE5 \| P00830 MIPS: YJR121W NCBI: 1015845 \| 119389907 \| 119389908 \| 119389909 \| 119389916 \| 119389917 \| 119389918 \| 119389925 \| 119389926 \| 119389927 \| 1483632 \| 171108 \| 171110 \| 224510811 \| 224510812 \| 224510813 \| 224510820 \| 224510821 \| 224510822 \| 224510829 \| 224510830 \| 224510831 \| 300193118 \| 300193119 \| 300193120 \| 306991952 \| 306991953 \| 306991954 \| 306991961 \| 306991962 \| 306991963 \| 306991970 \| 306991971 \| 306991972 \| 306991979 \| 306991980 \| 306991981 \| 306991988 \| 306991989 \| 306991990 \| 306991997 \| 306991998 \| 306991999 \| 306992006 \| 306992007 \| 306992008 \| 306992015 \| 306992016 \| 306992017 \| 306992024 \| 306992025 \| 306992026 \| 306992033 \| 306992034 \| 306992035 \| 306992042 \| 306992043 \| 306992044 \| 306992051 \| 306992052 \| 306992053 \| 307568101 \| 307568102 \| 307568103 \| 3396 \| 372467208 \| 372467209 \| 372467210 \| 398365477 \| 402550244 \| 402550245 \| 402550246 \| 449802273 \| 449802274 \| 449802275 \| 449802283 \| 449802284 \| 449802285 \| 84028178 \| NP_012655.3 GenBank/EMBL/DDBJ: DAA08906.1 \| K00560 \| M12082 \| U46215 \| X52004 \| Z49621
External Classifications	EC: 3.6.3.14 [H(+)-transporting two-sector ATPase]

Amino Acid Sequence (or in FASTA format)
1 MVLPRLYTAT SRAAFKAAKQ SAPLLSTSWK RCMASAAQST PITGKVTAVI 51 GAIVDVHFEQ SELPAILNAL EIKTPQGKLV LEVAQHLGEN TVRTIAMDGT 101 EGLVRGEKVL DTGGPISVPV GRETLGRIIN VIGEPIDERG PIKSKLRKPI 151 HADPPSFAEQ STSAEILETG IKVVDLLAPY ARGGKIGLFG GAGVGKTVFI 201 QELINNIAKA HGGFSVFTGV GERTREGNDL YREMKETGVI NLEGESKVAL 251 VFGQMNEPPG ARARVALTGL TIAEYFRDEE GQDVLLFIDN IFRFTQAGSE 301 VSALLGRIPS AVGYQPTLAT DMGLLQERIT TTKKGSVTSV QAVYVPADDL 351 TDPAPATTFA HLDATTVLSR GISELGIYPA VDPLDSKSRL LDAAVVGQEH 401 YDVASKVQET LQTYKSLQDI IAILGMDELS EQDKLTVERA RKIQRFLSQP 451 FAVAEVFTGI PGKLVRLKDT VASFKAVLEG KYDNIPEHAF YMVGGIEDVV 501 AKAEKLAAEA N*

Amino Acid Sequence (or in FASTA format)

       1  MVLPRLYTAT SRAAFKAAKQ SAPLLSTSWK RCMASAAQST PITGKVTAVI
      51  GAIVDVHFEQ SELPAILNAL EIKTPQGKLV LEVAQHLGEN TVRTIAMDGT
     101  EGLVRGEKVL DTGGPISVPV GRETLGRIIN VIGEPIDERG PIKSKLRKPI
     151  HADPPSFAEQ STSAEILETG IKVVDLLAPY ARGGKIGLFG GAGVGKTVFI
     201  QELINNIAKA HGGFSVFTGV GERTREGNDL YREMKETGVI NLEGESKVAL
     251  VFGQMNEPPG ARARVALTGL TIAEYFRDEE GQDVLLFIDN IFRFTQAGSE
     301  VSALLGRIPS AVGYQPTLAT DMGLLQERIT TTKKGSVTSV QAVYVPADDL
     351  TDPAPATTFA HLDATTVLSR GISELGIYPA VDPLDSKSRL LDAAVVGQEH
     401  YDVASKVQET LQTYKSLQDI IAILGMDELS EQDKLTVERA RKIQRFLSQP
     451  FAVAEVFTGI PGKLVRLKDT VASFKAVLEG KYDNIPEHAF YMVGGIEDVV
     501  AKAEKLAAEA N*

external links for Atp2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Atp2p

1)	Takeda M, et al. (1985) Nuclear genes coding the yeast mitochondrial adenosine triphosphatase complex. Primary sequence analysis of ATP2 encoding the F1-ATPase beta-subunit precursor. J Biol Chem 260(29):15458-65
2)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41