YMR1/YJR110W Protein Information Help

Standard Name Ymr1p 1
Systematic Name Yjr110wp
ORF Classification Verified
Description Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family (1, 2)
Name Description Yeast Myotubularin Related 1
Experimental Data
Molecules/cell 1080 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 688
Molecular Weight (Da) 80,151
Isoelectric Point (pI) 7.58

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ymr1p (InterPro)
Physical Interactions There are 14 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B4DD | P47147
MIPS: YJR110W
NCBI: 1015824 | 1352911 | 6322570 | 808831 | 808832 | NP_012644.1 | NM_001181768.1
GenBank/EMBL/DDBJ: DAA08895.1 | K01178 | M30466 | Z49610
External Classifications EC: 3.1.3.- [Phosphoric Monoester Hydrolases]
EC: 3.1.3.64 [Phosphatidylinositol-3-phosphatase]
Amino Acid Sequence (or in FASTA format)
 
       1  MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI
      51  YGVHKNPGST LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK
     101  DYAVFSLDFG GDLHLQARKV YDSILNLTVL SNITQLYAFI YISNNLERKL
     151  PSPDSWDIYD PIKEFRRQGL DSKDETCPWR LSTVNEHYEF CPTYPSKLFV
     201  PRSTSDILLK HASKFRSQKR IPVLTYHHKA TDCNILRSSQ PLPGLINQRS
     251  IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA LGGGTENMDN
     301  YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD
     351  LNLPLEQNLI RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG
     401  WDRTSQVVSL LEICLDPFYR TFEGFMILVE KDWCSFGHRF LERSGHLNSD
     451  IRFHDNTMHS NFNDVDTNGD DLDIGVNTQD DYAEDDEGGE DETNLINLSR
     501  ISKKFNENFK LNKKSLKFVS PVFQQFLDCV YQLLTQNPDL FEFNERFLRR
     551  LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR RKQFINPNFI
     601  QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH
     651  KRDSVPISVD KKSKEHSNSD GGKGLNLSIF GFDMFNRK*

external links for Ymr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Ymr1p
1) Taylor GS, et al.  (2000) Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A 97(16):8910-5
2) Parrish WR, et al.  (2004) Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast. Mol Biol Cell 15(8):3567-79
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41