IME1/YJR094C Protein Information

Standard Name	Ime1p 1
Systematic Name	Yjr094cp
ORF Classification	Verified
Description	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p (2, 3)
Name Description	Inducer of MEiosis 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	360
Molecular Weight (Da)	41,858
Isoelectric Point (pI)	5.01

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ime1p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012D61A \| P21190 \| B8XW28 MIPS: YJR094C NCBI: 124393 \| 6322553 \| NP_012627.1 GenBank/EMBL/DDBJ: DAA08878.1 \| M37188 \| X52152 \| Z49594

Amino Acid Sequence (or in FASTA format)
1 MQADMHGKLH AALEDGFFLF PFEQQQQPNI YYDTTTDQED RPCFSFGSTI 51 SPRSWHFEKS DKIASSQLQN LVHTQPIHLI NPQILFNEEF LNLENIDSQP 101 ISKETKTTKD CTMATGPERG KKSSESTRSS SLSSLFSNDE SASTFHSSFN 151 NHDNFQKSNR NGDDIDISDT IKYETNTNAQ KDIKIFQENF EFNEFPYTQD 201 FYPYTTNYTY SKPTNIHESI NSKNTDSYSQ YQDQFPPHTD NIHSFNNRHY 251 SNHKSTNCNY YNNTSNNNNA SDNVYEADPF IDEPQVPSYY YPLEIAFDVE 301 KSPPPSLQKL NSKELEFLKK LNSKLSRYAA AYSFSSSNDQ DYYDKVRFQE 351 ISYKFSKTYS *

Amino Acid Sequence (or in FASTA format)

       1  MQADMHGKLH AALEDGFFLF PFEQQQQPNI YYDTTTDQED RPCFSFGSTI
      51  SPRSWHFEKS DKIASSQLQN LVHTQPIHLI NPQILFNEEF LNLENIDSQP
     101  ISKETKTTKD CTMATGPERG KKSSESTRSS SLSSLFSNDE SASTFHSSFN
     151  NHDNFQKSNR NGDDIDISDT IKYETNTNAQ KDIKIFQENF EFNEFPYTQD
     201  FYPYTTNYTY SKPTNIHESI NSKNTDSYSQ YQDQFPPHTD NIHSFNNRHY
     251  SNHKSTNCNY YNNTSNNNNA SDNVYEADPF IDEPQVPSYY YPLEIAFDVE
     301  KSPPPSLQKL NSKELEFLKK LNSKLSRYAA AYSFSSSNDQ DYYDKVRFQE
     351  ISYKFSKTYS *

external links for Ime1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ime1p

1)	Kassir Y, et al. (1988) IME1, a positive regulator gene of meiosis in S. cerevisiae. Cell 52(6):853-62
2)	Guttmann-Raviv N, et al. (2002) Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Mol Cell Biol 22(7):2047-56
3)	Kassir Y, et al. (2003) Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol 224():111-71