BIR1/YJR089W Protein Information Help

Standard Name Bir1p 1
Systematic Name Yjr089wp
ORF Classification Verified
Description Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress (2, 3, 4, 5, 6)
Name Description Baculoviral IAP Repeat-containing protein 1, 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 954
Molecular Weight (Da) 108,666
Isoelectric Point (pI) 6.41

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Bir1p (InterPro)
Physical Interactions There are 61 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001269A3 | P47134
MIPS: YJR089W
NCBI: 1015782 | 1019708 | 1352900 | 398365267 | NP_012622.3
GenBank/EMBL/DDBJ: DAA08873.1 | L47993 | Z49589
Amino Acid Sequence (or in FASTA format)
 
       1  MDGQIDKMEK RYSMTKLENR LRTFQDGVAL EKKKLKWSFK VIPYQAMAKL
      51  GFYFDPVIDP KTSKLKKDSV RCCYCHRQTY NVRDCRSKRK DVLETLSNIM
     101  RQHLTVTDNK QVCLLIYLRN KLLTDYSFHM GVSDWKNDKY FSNPDDENVI
     151  NLRKFTFQDN WPHSGSQNEH PLGIEKMVNA GLMRYDSSIE GLGDPSMDKT
     201  LMNDTCYCIY CKQLLQGWSI NDDPMSRHYK VSQNGNCYFF QTRNRFERIK
     251  NDNDSITKNC EVSPTLGENG KREVINTKTA SQRQCPLFES PPSSTGPQLD
     301  DYNEKTDISV IQHNISVLDG AQGENVKRNS VEEKEQINME NGSTTLEEGN
     351  INRDVLADKK EVISTPTAKE IKRPNVQLTQ SSSPIKKKRK FKRISPRKIF
     401  DEEDSEHSLN NNSANGDNKD KDLVIDFTSH IIKNRDVGRK NAILDDSTDE
     451  FSFSNQGHNT FDIPIPTSSH LLKGIDSDND NVIREDDTGI NTDTKGASSK
     501  HEKFSVNSEE DLNFSEVKLT GRDSSTNILI RTQIVDQNLG DIDRDKVPNG
     551  GSPEVPKTHE LIRDNSEKRE AQNGEFRHQK DSTVRQSPDI LHSNKSGDNS
     601  SNITAIPKEE QRRGNSKTSS IPADIHPKPR KNLQEPRSLS ISGKVVPTER
     651  KLDNINIDLN FSASDFSPSS QSEQSSKSSS VISTPVASPK INLTRSLHAV
     701  KELSGLKKET DDGKYFTNKQ ETIKILEDVS VKNETPNNEM LLFETGTPIA
     751  SQENKSRKLF DEEFSGKELD IPIDSSTVEI KKVIKPEFEP VPSVARNLVS
     801  GTSSYPRNSR LEEQRKETST SLADNSKKGS SFNEGNNEKE PNAAEWFKID
     851  ENRHLVKNYF HDLLKYINNN DATLANDKDG DLAFLIKQMP AEELDMTFNN
     901  WVNLKVQSIK REFIDDCDKK LDILRRDYYT ATNFIETLED DNQLIDIAKK
     951  MGIL*

external links for Bir1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Bir1p
1) Uren AG, et al.  (1999) Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division. Proc Natl Acad Sci U S A 96(18):10170-5
2) Yoon HJ and Carbon J  (1999) Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Proc Natl Acad Sci U S A 96(23):13208-13
3) Li F, et al.  (2000) Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast. J Biol Chem 275(10):6707-11
4) Nakajima Y, et al.  (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84
5) Makrantoni V and Stark MJ  (2009) Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1. Mol Cell Biol 29(16):4552-62
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76