EMC2/YJR088C Protein Information

Standard Name	Emc2p 1
Systematic Name	Yjr088cp
ORF Classification	Verified
Description	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 (1, 2)
Name Description	ER Membrane protein Complex 1

Experimental Data
Molecules/cell	5740 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	292
Molecular Weight (Da)	33,855
Isoelectric Point (pI)	5.44

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Emc2p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B4CA \| P47133 MIPS: YJR088C NCBI: 1015780 \| 1019707 \| 1352899 \| 51830436 \| 6322547 \| NP_012621.1 GenBank/EMBL/DDBJ: DAA08872.1 \| AY723838 \| L47993 \| Z49586

Amino Acid Sequence (or in FASTA format)
1 MLKDLVREKL LTIMNTKAYT QFNPEQLLQL ENEMKIYMKS GDSALTEGNY 51 FFLMEMLFYV LVYRNQDVDA QVVYNTLRDR LGENSYKMVI MKATLLQING 101 NDKGAIEYLE NLLNDDLEYE TDFVTYVSIA KKLIAIKTTS KNLSQESVLK 151 EVVALTDKFP LDAELWWYAS EIYFEMGQFE KACYCLEQVL CITPFNYACF 201 GRLSETLYYE ALRSKKQTKT ELLEKALKNA LRSVELSELY LKGWALVNII 251 SRELGRNKQN DLIKLSASKL KEISAKSNNK DKITAELILN KI*

Amino Acid Sequence (or in FASTA format)

       1  MLKDLVREKL LTIMNTKAYT QFNPEQLLQL ENEMKIYMKS GDSALTEGNY
      51  FFLMEMLFYV LVYRNQDVDA QVVYNTLRDR LGENSYKMVI MKATLLQING
     101  NDKGAIEYLE NLLNDDLEYE TDFVTYVSIA KKLIAIKTTS KNLSQESVLK
     151  EVVALTDKFP LDAELWWYAS EIYFEMGQFE KACYCLEQVL CITPFNYACF
     201  GRLSETLYYE ALRSKKQTKT ELLEKALKNA LRSVELSELY LKGWALVNII
     251  SRELGRNKQN DLIKLSASKL KEISAKSNNK DKITAELILN KI*

external links for Emc2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Emc2p

1)	Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
2)	Richard M, et al. (2013) Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Proc Natl Acad Sci U S A 110(11):E1055-63
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41