STE18/YJR086W Protein Information Help

Standard Name Ste18p 1
Systematic Name Yjr086wp
ORF Classification Verified
Description G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling (2, 3)
Name Description STErile
Experimental Data
Molecules/cell 5550 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 110
Molecular Weight (Da) 12,625
Isoelectric Point (pI) 10.35

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ste18p (InterPro)
Physical Interactions There are 17 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000011363D | P18852
MIPS: YJR086W
NCBI: 1015778 | 1019705 | 121018 | 172743 | 45269667 | 6322545 | NP_012619.1
GenBank/EMBL/DDBJ: DAA08871.1 | AY557888 | L47993 | M23983 | Z49586
Amino Acid Sequence (or in FASTA format)
 
       1  MTSVQNSPRL QQPQEQQQQQ QQLSLKIKQL KLKRINELNN KLRKELSRER
      51  ITASNACLTI INYTSNTKDY TLPELWGYPV AGSNHFIEGL KNAQKNSQMS
     101  NSNSVCCTLM *

external links for Ste18p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Ste18p
1) Whiteway M, et al.  (1988) Expression of MF alpha 1 in MATa cells supersensitive to alpha-factor leads to self-arrest. Mol Gen Genet 214(1):85-8
2) Whiteway M, et al.  (1989) The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein. Cell 56(3):467-77
3) Hirschman JE and Jenness DD  (1999) Dual lipid modification of the yeast ggamma subunit Ste18p determines membrane localization of Gbetagamma. Mol Cell Biol 19(11):7705-11
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41