CDC11/YJR076C Protein Information

Standard Name	Cdc11p
Systematic Name	Yjr076cp
Alias	Psl9p
ORF Classification	Verified
Description	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells (1, 2, 3, 4, 5, 6)
Name Description	Cell Division Cycle 7

Experimental Data
Molecules/cell	9280 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	415
Molecular Weight (Da)	47,648
Isoelectric Point (pI)	4.76

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cdc11p (InterPro)
Physical Interactions	There are 171 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F0AC \| P32458 MIPS: YJR076C NCBI: 1015762 \| 1019697 \| 295594 \| 416760 \| 6322536 \| NP_012610.1 GenBank/EMBL/DDBJ: DAA08862.1 \| L16550 \| L47993 \| Z49576

Amino Acid Sequence (or in FASTA format)
1 MSGIIDASSA LRKRKHLKRG ITFTVMIVGQ SGSGRSTFIN TLCGQQVVDT 51 STTILLPTDT STEIDLQLRE ETVELEDDEG VKIQLNIIDT PGFGDSLDNS 101 PSFEIISDYI RHQYDEILLE ESRVRRNPRF KDGRVHCCLY LINPTGHGLK 151 EIDVEFIRQL GSLVNIIPVI SKSDSLTRDE LKLNKKLIME DIDRWNLPIY 201 NFPFDEDEIS DEDYETNMYL RTLLPFAIIG SNEVYEMGGD VGTIRGRKYP 251 WGILDVEDSS ISDFVILRNA LLISHLHDLK NYTHEILYER YRTEALSGES 301 VAAESIRPNL TKLNGSSSSS TTTRRNTNPF KQSNNINNDV LNPASDMHGQ 351 STGENNETYM TREEQIRLEE ERLKAFEERV QQELLLKRQE LLQREKELRE 401 IEARLEKEAK IKQEE*

Amino Acid Sequence (or in FASTA format)

       1  MSGIIDASSA LRKRKHLKRG ITFTVMIVGQ SGSGRSTFIN TLCGQQVVDT
      51  STTILLPTDT STEIDLQLRE ETVELEDDEG VKIQLNIIDT PGFGDSLDNS
     101  PSFEIISDYI RHQYDEILLE ESRVRRNPRF KDGRVHCCLY LINPTGHGLK
     151  EIDVEFIRQL GSLVNIIPVI SKSDSLTRDE LKLNKKLIME DIDRWNLPIY
     201  NFPFDEDEIS DEDYETNMYL RTLLPFAIIG SNEVYEMGGD VGTIRGRKYP
     251  WGILDVEDSS ISDFVILRNA LLISHLHDLK NYTHEILYER YRTEALSGES
     301  VAAESIRPNL TKLNGSSSSS TTTRRNTNPF KQSNNINNDV LNPASDMHGQ
     351  STGENNETYM TREEQIRLEE ERLKAFEERV QQELLLKRQE LLQREKELRE
     401  IEARLEKEAK IKQEE*

external links for Cdc11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cdc11p

1)	Takizawa PA, et al. (2000) Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290(5490):341-4
2)	Gladfelter AS, et al. (2001) The septin cortex at the yeast mother-bud neck. Curr Opin Microbiol 4(6):681-9
3)	Hanrahan J and Snyder M (2003) Cytoskeletal activation of a checkpoint kinase. Mol Cell 12(3):663-73
4)	Versele M, et al. (2004) Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell 15(10):4568-83
5)	Vrabioiu AM, et al. (2004) The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem 279(4):3111-8
6)	McMurray MA, et al. (2011) Septin filament formation is essential in budding yeast. Dev Cell 20(4):540-9
7)	Hartwell LH, et al. (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41