CDC11/YJR076C Protein Information Help

Standard Name Cdc11p 1
Systematic Name Yjr076cp
Alias Psl9p
ORF Classification Verified
Description Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells (2, 3, 4, 5, 6, 7)
Name Description Cell Division Cycle 8
Experimental Data
Molecules/cell 9280 9
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 415
Molecular Weight (Da) 47,648
Isoelectric Point (pI) 4.76

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cdc11p (InterPro)
Physical Interactions There are 176 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F0AC | P32458
MIPS: YJR076C
NCBI: 1015762 | 1019697 | 295594 | 416760 | 6322536 | NP_012610.1 | NM_001181734.1
GenBank/EMBL/DDBJ: AAB39301.1 | AAB50035.1 | CAA89604.1 | DAA08862.1 | L16550 | L47993 | Z49576
Amino Acid Sequence (or in FASTA format)
       1  MSGIIDASSA LRKRKHLKRG ITFTVMIVGQ SGSGRSTFIN TLCGQQVVDT
      51  STTILLPTDT STEIDLQLRE ETVELEDDEG VKIQLNIIDT PGFGDSLDNS
     101  PSFEIISDYI RHQYDEILLE ESRVRRNPRF KDGRVHCCLY LINPTGHGLK
     151  EIDVEFIRQL GSLVNIIPVI SKSDSLTRDE LKLNKKLIME DIDRWNLPIY
     201  NFPFDEDEIS DEDYETNMYL RTLLPFAIIG SNEVYEMGGD VGTIRGRKYP
     251  WGILDVEDSS ISDFVILRNA LLISHLHDLK NYTHEILYER YRTEALSGES
     301  VAAESIRPNL TKLNGSSSSS TTTRRNTNPF KQSNNINNDV LNPASDMHGQ
     351  STGENNETYM TREEQIRLEE ERLKAFEERV QQELLLKRQE LLQREKELRE
     401  IEARLEKEAK IKQEE*                                     

external links for Cdc11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Aspergillus (AspGD) CYC2008 (complexes) MIPS YPL+
Candida (CGD) Complexome Pfam domains YeastGFP
YGOB DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository
YOGY GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cdc11p
1) Hartwell LH  (1971) Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res 69(2):265-76
2) Takizawa PA, et al.  (2000) Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290(5490):341-4
3) Gladfelter AS, et al.  (2001) The septin cortex at the yeast mother-bud neck. Curr Opin Microbiol 4(6):681-9
4) Hanrahan J and Snyder M  (2003) Cytoskeletal activation of a checkpoint kinase. Mol Cell 12(3):663-73
5) Versele M, et al.  (2004) Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol Biol Cell 15(10):4568-83
6) Vrabioiu AM, et al.  (2004) The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem 279(4):3111-8
7) McMurray MA, et al.  (2011) Septin filament formation is essential in budding yeast. Dev Cell 20(4):540-9
8) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
9) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41