ARP3/YJR065C Protein Information

Standard Name	Arp3p 1
Systematic Name	Yjr065cp
Alias	Act4p
ORF Classification	Verified
Description	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity (1, 2, 3)
Name Description	Actin-Related Protein 1

Experimental Data
Molecules/cell	6650 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	449
Molecular Weight (Da)	49,541
Isoelectric Point (pI)	5.6

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arp3p (InterPro)
Physical Interactions	There are 90 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531DC \| P47117 MIPS: YJR065C NCBI: 1015741 \| 1019687 \| 1168331 \| 1220556 \| 398365101 \| NP_012599.3 \| NM_001181723.3 GenBank/EMBL/DDBJ: DAA08852.1 \| L37111 \| L47993 \| Z49565

Amino Acid Sequence (or in FASTA format)
1 MSYLNNPAVV MDNGTGLTKL GFAGNDSPSW VFPTAIATAA PSNTKKSSGV 51 GAPSAVSNEA SYFGNSTSAT NFNGATGGLL SNNLSGKRGT EDLDFYIGNE 101 ALVASQGPSY SLSYPIRHGQ VENWDHMERF WENSIFKYLR TEPEDHFFLL 151 TEPPLNPPEN REQVAEIFFE SFNCAGLYIA VQAVLALAAS WTSSKVTDRS 201 LTGTVIDSGD GVTHVIPVAE GYVIGSAIKN IPIAGRDITL FIQSLLRERG 251 EADTSLRTAE KIKQEYCYVC PDIVKEFNKF DKDPSKFAQF VVENQEKTRR 301 KVVDIGYERF LAPEIFFNPE IASSDFLTPL PTVVDQTIQA CPIDVRKGLY 351 NNIVLSGGST MFKDFGRRLQ RDLKSIVNNR IAQSELLSGT KSTGVDVSVI 401 SHRKQRNAVW FGGSLLAQTA EFKGYCHTKK DYEEYGPEIV RNFSLFNMV*

Amino Acid Sequence (or in FASTA format)

       1  MSYLNNPAVV MDNGTGLTKL GFAGNDSPSW VFPTAIATAA PSNTKKSSGV
      51  GAPSAVSNEA SYFGNSTSAT NFNGATGGLL SNNLSGKRGT EDLDFYIGNE
     101  ALVASQGPSY SLSYPIRHGQ VENWDHMERF WENSIFKYLR TEPEDHFFLL
     151  TEPPLNPPEN REQVAEIFFE SFNCAGLYIA VQAVLALAAS WTSSKVTDRS
     201  LTGTVIDSGD GVTHVIPVAE GYVIGSAIKN IPIAGRDITL FIQSLLRERG
     251  EADTSLRTAE KIKQEYCYVC PDIVKEFNKF DKDPSKFAQF VVENQEKTRR
     301  KVVDIGYERF LAPEIFFNPE IASSDFLTPL PTVVDQTIQA CPIDVRKGLY
     351  NNIVLSGGST MFKDFGRRLQ RDLKSIVNNR IAQSELLSGT KSTGVDVSVI
     401  SHRKQRNAVW FGGSLLAQTA EFKGYCHTKK DYEEYGPEIV RNFSLFNMV*

external links for Arp3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Arp3p

1)	Poch O and Winsor B (1997) Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Yeast 13(11):1053-8
2)	Winter D, et al. (1997) The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol 7(7):519-29
3)	Huang ME, et al. (1996) Identification of ACT4, a novel essential actin-related gene in the yeast Saccharomyces cerevisiae. Yeast 12(9):839-48
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41