PTK2/YJR059W Protein Information Help

Standard Name Ptk2p 1
Systematic Name Yjr059wp
Alias Stk2p 2
ORF Classification Verified
Description Putative serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication (1, 3, 4)
Name Description Putative serine/Threonine protein Kinase
Experimental Data
Molecules/cell 1420 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 818
Molecular Weight (Da) 91,400
Isoelectric Point (pI) 9.52

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ptk2p (InterPro)
Physical Interactions There are 220 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000132948 | P47116
MIPS: YJR059W
NCBI: 1015729 | 1019681 | 1346383 | 1772440 | 398365059 | 51830428 | NP_012593.3 | NM_001181717.3
GenBank/EMBL/DDBJ: DAA08846.1 | AY723837 | D87274 | L47993 | Z49559
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MAGNGKDKEV DKSPSVSTLK LLGKRLFNSS SHTDNSSLLL SAEQLGNGRS
      51  LRKRPTSPSI SGSGSGGNSP SSSAGARQRS ASLHRRKNNA SVGFSNGSVS
     101  SHKSSVALQD LIKHNNNPYL NSPSDILGTG TGIASTRDRD RAVLDREKEK
     151  ERARNKERNT HHAGLPQRSN SMASHHFPNE NIVYNPYGIS PNHARPDTAF
     201  ADTLNTNKEN DLSFYMHDGN SKIRMLPLPI ANPNDFLPED MKQYSVHLTD
     251  NFVFDTDNKP IGSGGSSEVR KVKSSYRQKD VYALKKLNMI YHESPEKFYK
     301  RCSKEFIIAK HLSHNVHITN TFYLLKVPTT TYTTRGWGFI MELGVKDLFQ
     351  LMERTGWKNV PFNEKYCLFK QVAQGIKFCH DNGIAHRDLK PENVLISKEG
     401  ICKLTDFGIS DWYHVIPHDY TSPVKTCQGM IGSPPYTPPE VMYFDAKKHY
     451  PEKFQKPYNP LAMDSYALGI MLITMINNII PFIDSCNTDA RFREFEVSYD
     501  NFINHQNPHF RDKGCHKPGP GSEYSLARNF KNTDATRIAW RLADPNPATR
     551  YTMDDLFNDP FFQQIETCVE PNDDDLVRVP ELRKSTSTND FSENSLDAPH
     601  DQEVIHTSNP FLKKETLTSK PRSMLEIAES PSLKQKSKVK DSAKTKTHDV
     651  GDEGGNESTK PKQQDKKENL KKDEVKNGDK DKVIEEATTT NVDSILEKPT
     701  PTSTKVEDNL SEDDSTMKEL KSMLNSTPTT PTHNGPTPLP AKAGTQLDKR
     751  MSDLSLKSET PASTKNFSAP NVSSSSNSLR SLGSPSVSSS KKKKVIHHHL
     801  DITNSVTNMS SVSAFISR*

external links for Ptk2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Ptk2p
1) Nozaki T, et al.  (1996) A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Biochem Biophys Res Commun 228(2):452-8
2) Kaouass M, et al.  (1997) The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae. Mol Cell Biol 17(6):2994-3004
3) Erez O and Kahana C  (2002) Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun 295(5):1142-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41