CYC1/YJR048W Protein Information Help

Standard Name Cyc1p
Systematic Name Yjr048wp
ORF Classification Verified
Description Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; mutations in human homolog cause insulin-responsive hyperglycemia; CYC1 has a paralog, CYC7, that arose from the whole genome duplication (1, 2, 3)
Name Description CYtochrome C
Gene Product iso-1-cytochrome c 4
Experimental Data
Molecules/cell 7330 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 109
Molecular Weight (Da) 12,182
Isoelectric Point (pI) 10.2

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cyc1p (InterPro)
Physical Interactions There are 24 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000141E45 | P00044
MIPS: YJR048W
NCBI: 1015707 | 117901 | 1197077 | 157831497 | 157831498 | 157834304 | 157834311 | 171258 | 185177519 | 194368471 | 20151140 | 28374078 | 29726401 | 334878387 | 334878388 | 334878389 | 334878390 | 334878391 | 334878392 | 334878393 | 334878394 | 334878395 | 334878396 | 334878398 | 334878399 | 334878400 | 334878401 | 334878404 | 334878434 | 359545621 | 3614 | 3627 | 413915769 | 425684927 | 433552093 | 443419 | 48425575 | 55670195 | 6322508 | 695795 | 82407965 | 82407967 | 82407971 | 82407975 | NP_012582.1 | NM_001181706.1
GenBank/EMBL/DDBJ: AAA62856.1 | AAA88751.1 | AAB59344.1 | CAA24605.1 | CAA27189.1 | CAA89576.1 | DAA08835.1 | L26347 | L36344 | M37696 | V01298 | X03472 | Z49548
Amino Acid Sequence (or in FASTA format)
       1  MTEFKAGSAK KGATLFKTRC LQCHTVEKGG PHKVGPNLHG IFGRHSGQAE
      51  GYSYTDANIK KNVLWDENNM SEYLTNPKKY IPGTKMAFGG LKKEKDRNDL
     101  ITYLKKACE*                                            

external links for Cyc1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Cyc1p
1) Berg J M, et al.  (2002) Biochemistry (5th edition)
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Gaignard P, et al.  (2013) Mutations in CYC1, Encoding Cytochrome c1 Subunit of Respiratory Chain Complex III, Cause Insulin-Responsive Hyperglycemia. Am J Hum Genet 93(2):384-9
4) Sherman F, et al.  (1966) The structural gene for yeast cytochrome C. Proc Natl Acad Sci U S A 55(6):1498-504
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41