TAH11/YJR046W Protein Information

Standard Name	Tah11p 1
Systematic Name	Yjr046wp
Alias	Sid2p 2 , Cdt1p 3
ORF Classification	Verified
Description	DNA replication licensing factor, required for pre-replication complex assembly (1, 3)
Name Description	Topo-A Hypersensitive 1

Experimental Data
Molecules/cell	2190 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	604
Molecular Weight (Da)	68,405
Isoelectric Point (pI)	8.71

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tah11p (InterPro)
Physical Interactions	There are 58 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B4A5 \| P47112 MIPS: YJR046W NCBI: 1015703 \| 1197074 \| 1352882 \| 6322506 \| NP_012580.1 GenBank/EMBL/DDBJ: DAA08833.1 \| L36344 \| Z49546

Amino Acid Sequence (or in FASTA format)
1 MSGTANSRRK EVLRVPVIDL NRVSDEEQLL PVVRAILLQH DTFLLKNYAN 51 KAVLDALLAG LTTKDLPDTS QGFDANFTGT LPLEDDVWLE QYIFDTDPQL 101 RFDRKCRNES LCSIYSRLFK LGLFFAQLCV KSVVSSAELQ DCISTSHYAT 151 KLTRYFNDNG STHDGADAGA TVLPTGDDFQ YLFERDYVTF LPTGVLTIFP 201 CAKAIRYKPS TMATTDNSWV SIDEPDCLLF HTGTLLARWS QGMHTTSPLQ 251 IDPRANIVSL TIWPPLTTPI SSKGEGTIAN HLLEQQIKAF PKVAQQYYPR 301 ELSILRLQDA MKFVKELFTV CETVLSLNAL SRSTGVPPEL HVLLPQISSM 351 MKRKIVQDDI LKLLTIWSDA YVVELNSRGE LTMNLPKRDN LTTLTNKSRT 401 LAFVERAESW YQQVIASKDE IMTDVPAFKI NKRRSSSNSK TVLSSKVQTK 451 SSNANALNNS RYLANSKENF MYKEKMPDSQ ANLMDRLRER ERRSAALLSQ 501 RQKRYQQFLA MKMTQVFDIL FSLTRGQPYT ETYLSSLIVD SLQDSNNPIG 551 TKEASEILAG LQGILPMDIS VHQVDGGLKV YRWNSLDKNR FSKLLQIHKS 601 KQQD*

Amino Acid Sequence (or in FASTA format)

       1  MSGTANSRRK EVLRVPVIDL NRVSDEEQLL PVVRAILLQH DTFLLKNYAN
      51  KAVLDALLAG LTTKDLPDTS QGFDANFTGT LPLEDDVWLE QYIFDTDPQL
     101  RFDRKCRNES LCSIYSRLFK LGLFFAQLCV KSVVSSAELQ DCISTSHYAT
     151  KLTRYFNDNG STHDGADAGA TVLPTGDDFQ YLFERDYVTF LPTGVLTIFP
     201  CAKAIRYKPS TMATTDNSWV SIDEPDCLLF HTGTLLARWS QGMHTTSPLQ
     251  IDPRANIVSL TIWPPLTTPI SSKGEGTIAN HLLEQQIKAF PKVAQQYYPR
     301  ELSILRLQDA MKFVKELFTV CETVLSLNAL SRSTGVPPEL HVLLPQISSM
     351  MKRKIVQDDI LKLLTIWSDA YVVELNSRGE LTMNLPKRDN LTTLTNKSRT
     401  LAFVERAESW YQQVIASKDE IMTDVPAFKI NKRRSSSNSK TVLSSKVQTK
     451  SSNANALNNS RYLANSKENF MYKEKMPDSQ ANLMDRLRER ERRSAALLSQ
     501  RQKRYQQFLA MKMTQVFDIL FSLTRGQPYT ETYLSSLIVD SLQDSNNPIG
     551  TKEASEILAG LQGILPMDIS VHQVDGGLKV YRWNSLDKNR FSKLLQIHKS
     601  KQQD*

external links for Tah11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome
	GeneMANIA

References cited on this page View Complete Literature Guide for Tah11p

1)	Devault A, et al. (2002) Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae. Curr Biol 12(8):689-94
2)	Jacobson MD, et al. (2001) Mutations in SID2, a novel gene in Saccharomyces cerevisiae, cause synthetic lethality with sic1 deletion and may cause a defect during S phase. Genetics 159(1):17-33
3)	Tanaka S and Diffley JF (2002) Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol 4(3):198-207
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41