SSC1/YJR045C Protein Information Help

Standard Name Ssc1p 1
Systematic Name Yjr045cp
Alias Ens1p 2
ORF Classification Verified
Description Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication (2, 3, 4, 5, 6) Also known as: mtHSP70
Name Description Stress-Seventy subfamily C
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 654
Molecular Weight (Da) 70,627
Isoelectric Point (pI) 5.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ssc1p (InterPro)
Physical Interactions There are 125 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000005323E | P0CS90
MIPS: YJR045C
NCBI: 1015701 | 1197073 | 391359302 | 6322505 | 717089 | NP_012579.1 | NM_001181703.1
GenBank/EMBL/DDBJ: DAA08832.1 | L36344 | M27229 | Z49545
Amino Acid Sequence (or in FASTA format)
 
       1  MLAAKNILNR SSLSSSFRIA TRLQSTKVQG SVIGIDLGTT NSAVAIMEGK
      51  VPKIIENAEG SRTTPSVVAF TKEGERLVGI PAKRQAVVNP ENTLFATKRL
     101  IGRRFEDAEV QRDIKQVPYK IVKHSNGDAW VEARGQTYSP AQIGGFVLNK
     151  MKETAEAYLG KPVKNAVVTV PAYFNDSQRQ ATKDAGQIVG LNVLRVVNEP
     201  TAAALAYGLE KSDSKVVAVF DLGGGTFDIS ILDIDNGVFE VKSTNGDTHL
     251  GGEDFDIYLL REIVSRFKTE TGIDLENDRM AIQRIREAAE KAKIELSSTV
     301  STEINLPFIT ADASGPKHIN MKFSRAQFET LTAPLVKRTV DPVKKALKDA
     351  GLSTSDISEV LLVGGMSRMP KVVETVKSLF GKDPSKAVNP DEAVAIGAAV
     401  QGAVLSGEVT DVLLLDVTPL SLGIETLGGV FTRLIPRNTT IPTKKSQIFS
     451  TAAAGQTSVE IRVFQGEREL VRDNKLIGNF TLAGIPPAPK GVPQIEVTFD
     501  IDADGIINVS ARDKATNKDS SITVAGSSGL SENEIEQMVN DAEKFKSQDE
     551  ARKQAIETAN KADQLANDTE NSLKEFEGKV DKAEAQKVRD QITSLKELVA
     601  RVQGGEEVNA EELKTKTEEL QTSSMKLFEQ LYKNDSNNNN NNNGNNAESG
     651  ETKQ*

external links for Ssc1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB GeneMANIA

YOGY YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Ssc1p
1) Craig EA, et al.  (1987) SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth. Proc Natl Acad Sci U S A 84(12):4156-60
2) Morishima N, et al.  (1990) A subunit of yeast site-specific endonuclease SceI is a mitochondrial version of the 70-kDa heat shock protein. J Biol Chem 265(25):15189-97
3) Lopez-Buesa P, et al.  (1998) The biochemical properties of the ATPase activity of a 70-kDa heat shock protein (Hsp70) are governed by the C-terminal domains. Proc Natl Acad Sci U S A 95(26):15253-8
4) Truscott KN, et al.  (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13
5) Liu Q, et al.  (2001) Mitochondrial Hsp70 Ssc1: role in protein folding. J Biol Chem 276(9):6112-8
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61