REC107/YJR021C Protein Information

Standard Name	Rec107p
Systematic Name	Yjr021cp
Alias	Mer2p
ORF Classification	Verified
Description	Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation (1, 2, 3, 4)
Name Description	RECombination 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	314
Molecular Weight (Da)	35,683
Isoelectric Point (pI)	6.92

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rec107p (InterPro)
Physical Interactions	There are 56 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EF16 \| P21651 MIPS: YJR021C NCBI: 1019811 \| 1170924 \| 171930 \| 171932 \| 2131095 \| 6322481 \| 758284 \| 854595 \| NP_012555.1 GenBank/EMBL/DDBJ: DAA08811.1 \| M38340 \| M60755 \| X85972 \| X87611 \| Z49519 \| Z49521

Amino Acid Sequence (or in FASTA format)
1 MVARGRTDEI STDVSEANSE HSLMITETSS PFRSIFSHSG KVANAGALEE 51 SDKQILEWAG KLELESMELR ENSDKLIKVL NENSKTLCKS LNKFNQLLEQ 101 DAATNGNVKT LIKDLASQIE NQLDKVSTAM LSKGDEKKTK SDSSYRQVLV 151 EEISRYNSKI TRHVTNKQHE TEKSMRCTQE MLFNVGSQLE DVHKVLLSLS 201 KDMHSLQTRQ TALEMAFREK ADHAYDRPDV SLNGTTLLHD MDEAHDKQRK 251 KSVPPPRMMV TRSMKRRRSS SPTLSTSQNH NSEDNDDASH RLKRAARTII 301 PWEELRPDTL ESEL*

Amino Acid Sequence (or in FASTA format)

       1  MVARGRTDEI STDVSEANSE HSLMITETSS PFRSIFSHSG KVANAGALEE
      51  SDKQILEWAG KLELESMELR ENSDKLIKVL NENSKTLCKS LNKFNQLLEQ
     101  DAATNGNVKT LIKDLASQIE NQLDKVSTAM LSKGDEKKTK SDSSYRQVLV
     151  EEISRYNSKI TRHVTNKQHE TEKSMRCTQE MLFNVGSQLE DVHKVLLSLS
     201  KDMHSLQTRQ TALEMAFREK ADHAYDRPDV SLNGTTLLHD MDEAHDKQRK
     251  KSVPPPRMMV TRSMKRRRSS SPTLSTSQNH NSEDNDDASH RLKRAARTII
     301  PWEELRPDTL ESEL*

external links for Rec107p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rec107p

1)	Ohta K, et al. (1998) Mutations in the MRE11, RAD50, XRS2, and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells. Proc Natl Acad Sci U S A 95(2):646-51
2)	Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88
3)	Malone RE, et al. (2004) The signal from the initiation of meiotic recombination to the first division of meiosis. Eukaryot Cell 3(3):598-609
4)	Li J, et al. (2006) Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation. Genetics 173(4):1969-81